『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hisaeda H (日) (読)
役割 (任意):
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学籍番号 (推奨):
[継承]
2. (英) Nagasawa H (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Maeda K (日) (読)
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4.前川 洋一
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[継承]
5. (英) Ishikawa H (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Ito Y (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Good A. R (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Himeno K (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Previously, we reported that the expression of hsp65 within and on host macrophages correlates closely with protection against infection with Toxoplasma gondii in mice. Herein, we propose that gamma delta T cells play a crucial role in the induction of hsp65 and also in the protective immune response to T. gondii. Intraperitoneal inoculation with this protozoan resulted in hsp65 being expressed on and in host peritoneal macrophages and resulted in an increase of T cells bearing the gamma delta receptor with Thy-1+ and Thy-1- phenotypes in the peritoneal cavity and spleen. When mice were depleted of gamma delta T cells by the administration of a mAb, hsp65 expression was markedly decreased. In contrast, the expression of this protein was rather enhanced and gamma delta T cells were prominently expanded in mice depleted of alpha beta T cells. The protection in mice treated with the mAb paralleled the magnitude of hsp65 expression. Mice depleted of gamma delta T cells died most frequently in the early stages of infection, whereas most of those depleted of alpha beta T cells survived the early stages of lethal infection with T. gondii. However, the latter group of mice did not definitely control the T. gondii infection in its late stages. IFN-gamma was not essential for either the expression of hsp65 or the resistance induced by gamma delta T cells, as demonstrated in mice treated with mAb to murine IFN-gamma. These findings indicated that gamma delta T cells having both the Thy-1+ and Thy-1- phenotypes contribute to hsp65 expression within and on macrophages in an IFN-gamma-independent manner. This, in turn, plays a role in the development of protective immunity during the early stage of this parasitic infection.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bacterial Proteins (日) (読) [継承]
3. (英) Blotting, Western (日) (読) [継承]
4. (英) Chaperonins (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Flow Cytometry (日) (読) [継承]
7. (英) Immunization, Passive (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9. (英) Interferon-gamma (日) (読) [継承]
10. (英) Lymphocyte Depletion (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred BALB C (日) (読) [継承]
13. (英) Microscopy, Immunoelectron (日) (読) [継承]
14. (英) Receptors, Antigen, T-Cell, gamma-delta (日) (読) [継承]
15.Tリンパ球 (T lymphocytes) [継承]
16. (英) Toxoplasma (日) (読) [継承]
17. (英) Toxoplasmosis, Animal (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 155 [継承]
(必須): 1 [継承]
(必須): 244 251 [継承]
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年月日 (必須): 西暦 1995年 7月 1日 (平成 7年 7月 1日) [継承]
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DOI (任意):
PMID (任意): 7602101    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Parasitology and Immunology, University of Tokushima, School of Medicine, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : H Hisaeda, H Nagasawa, K Maeda, Yoichi Maekawa, H Ishikawa, Y Ito, R A. Good and K Himeno : Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii., The Journal of Immunology, Vol.155, No.1, 244-251, (発行所), (都市), July 1995.
欧文冊子 ● (種別) : H Hisaeda, H Nagasawa, K Maeda, Yoichi Maekawa, H Ishikawa, Y Ito, R A. Good and K Himeno : Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii., The Journal of Immunology, Vol.155, No.1, 244-251, (発行所), (都市), July 1995.

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