『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=193202EID:193202, Map:0, LastModified:2012年10月26日(金) 11:22:40, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hisaeda H (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Sakai T (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Nagasawa H (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Ishikawa H (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Yasutomo K (日) (読)
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学籍番号 (推奨):
[継承]
6.前川 洋一
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学籍番号 (推奨):
[継承]
7. (英) Himeno K (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We demonstrated that gamma delta T cells contribute to protective immunity against Toxoplasma gondii by inducing the expression of a 65,000 MW heat-shock protein (hsp 65) in host macrophages. Here we examined the role of extrathymic and intrathymic gamma delta T cells in protective immunity and hsp 65 expression in mice infected with T. gondii. Intrathymic gamma delta T cells were obtained from severe combined immunodeficiency (SCID) mice grafted with syngeneic fetal thymus (TG-SCID), in which only T cells derived from the donor thymus developed, whereas extrathymic gamma delta T cells were obtained from nude mice that lack thymus. Extrathymic gamma delta T cells from T. gondii-infected nude mice differed from intrathymic gamma delta T cells of infected TG-SCID mice, in terms of Thy1.2 expression and V-region gene usage of T-cell receptor (TCR) gamma delta. Extrathymic gamma delta T cells expressed extremely high levels of Thy1.2, and had V gamma 7 repertoire but lacked V gamma 5,6 and V delta 1,5. On the other hand, intrathymic gamma delta T cells express intermediate and low levels of Thy1,2. These cells possessed V gamma 5,6 and V delta 1,5 but failed to rearrange the V gamma 7 gene. Peritoneal macrophages from infected nude mice contained hsp 65, whereas this protein was scarcely expressed in those of infected TG-SCID mice. Transfer of extrathymic, but not of intrathymic gamma delta T cells to SCID mice enabled their macrophages to express hsp 65. Athymic nude mice were significantly resistant to the infection compared with SCID mice which lack gamma delta T as well as alpha beta T cells. The resistance was dependent upon extrathymic gamma delta T cells, since nude mice depleted of gamma delta T cells using a corresponding monoclonal antibody became extremely susceptible. These results indicated that extrathymic rather than intrathymic gamma delta T cells play some crucial roles in protection against T. gondii and in hsp 65 expression.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bacterial Proteins (日) (読) [継承]
3. (英) Base Sequence (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Chaperonins (日) (読) [継承]
6. (英) Macrophages, Peritoneal (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Mice, Inbred BALB C (日) (読) [継承]
9. (英) Mice, Inbred Strains (日) (読) [継承]
10. (英) Mice, Nude (日) (読) [継承]
11. (英) Molecular Sequence Data (日) (読) [継承]
12. (英) Peritoneal Cavity (日) (読) [継承]
13. (英) Polymerase Chain Reaction (日) (読) [継承]
14. (英) Receptors, Antigen, T-Cell, gamma-delta (日) (読) [継承]
15. (英) T-Lymphocyte Subsets (日) (読) [継承]
16. (英) Toxoplasmosis, Animal (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)

ISSN (任意): 0019-2805
ISSN: 0019-2805 (pISSN: 0019-2805, eISSN: 1365-2567)
Title: Immunology
Title(ISO): Immunology
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 88 [継承]
(必須): 4 [継承]
(必須): 551 557 [継承]
都市 (任意):
年月日 (必須): 西暦 1996年 8月 初日 (平成 8年 8月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 8881756    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Parasitology and Immunology, University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1456633  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : H Hisaeda, T Sakai, H Nagasawa, H Ishikawa, K Yasutomo, Yoichi Maekawa and K Himeno : Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii., Immunology, Vol.88, No.4, 551-557, (発行所), (都市), Aug. 1996.
欧文冊子 ● (種別) : H Hisaeda, T Sakai, H Nagasawa, H Ishikawa, K Yasutomo, Yoichi Maekawa and K Himeno : Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii., Immunology, Vol.88, No.4, 551-557, (発行所), (都市), Aug. 1996.

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