『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=193199)

EID=193199EID:193199, Map:0, LastModified:2012年10月26日(金) 11:22:40, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.前川 洋一
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Himeno K (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ishikawa H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Hisaeda H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Sakai T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Dainichi T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Asao T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Good A. R (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Katunuma N (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) When activated, CD4+ T helper cells differentiate functionally into one of two subsets, Th1 or Th2. Before the Th differentiation, Ags must be processed into peptide epitopes and presented to CD4+ T cells in association with MHC class II molecules. However, the proteases responsible for this Ag processing have not been well defined. When BALB/c mice susceptible to infection with Leishmania major were treated with a specific inhibitor (CA074) of cathepsin B, a lysosomal cysteine protease that digests exogenous antigenic proteins, those mice acquired resistance against infection with L. major and showed the shift of immune responses from Th2 to Th1; that is, they produced specific IgG2a Ab and generated IFN-gamma in contrast to untreated and infected mice that produced IgG1 and IgE and generated IL-4. CA074 interfered with the digestion of L. major Ags with lysosomal enzymes in vivo as well as in vitro. However, this inhibitor did not show any direct influence on the growth of L. major and the functions of T cells stimulated with anti-CD3 Ab. These findings indicate that cathepsin B inhibitor could switch CD4+ T cell differentiation from Th2 to Th1, suggesting that the alteration in Ag processing modulates the polarity of Th differentiation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, Protozoan (日) (読) [継承]
3. (英) Cathepsin B (日) (読) [継承]
4.細胞分化 (cell differentiation) [継承]
5. (英) Cysteine Proteinase Inhibitors (日) (読) [継承]
6. (英) Dipeptides (日) (読) [継承]
7. (英) Enzyme Activation (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9.自然免疫 (innate immunity) [継承]
10. (英) Immunoglobulins (日) (読) [継承]
11. (英) Immunophenotyping (日) (読) [継承]
12. (英) Leishmania major (日) (読) [継承]
13. (英) Leishmaniasis, Cutaneous (日) (読) [継承]
14. (英) Lymph Nodes (日) (読) [継承]
15. (英) Lysosomes (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Mice, Inbred BALB C (日) (読) [継承]
18. (英) Mice, Inbred DBA (日) (読) [継承]
19. (英) Mice, SCID (日) (読) [継承]
20. (英) Recurrence (日) (読) [継承]
21. (英) Spleen (日) (読) [継承]
22. (英) Th1 Cells (日) (読) [継承]
23. (英) Th2 Cells (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 161 [継承]
(必須): 5 [継承]
(必須): 2120 2127 [継承]
都市 (任意):
年月日 (必須): 西暦 1998年 9月 1日 (平成 10年 9月 1日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 9725203    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Parasitology and Immunology, University of Tokushima School of Medicine, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Yoichi Maekawa, K Himeno, H Ishikawa, H Hisaeda, T Sakai, T Dainichi, T Asao, R A. Good and N Katunuma : Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis., The Journal of Immunology, Vol.161, No.5, 2120-2127, (発行所), (都市), Sep. 1998.
欧文冊子 ● (種別) : Yoichi Maekawa, K Himeno, H Ishikawa, H Hisaeda, T Sakai, T Dainichi, T Asao, R A. Good and N Katunuma : Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis., The Journal of Immunology, Vol.161, No.5, 2120-2127, (発行所), (都市), Sep. 1998.

関連情報

Number of session users = 0, LA = 0.48, Max(EID) = 383285, Max(EOID) = 1024421.