『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=193196EID:193196, Map:0, LastModified:2012年10月26日(金) 12:02:13, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sakai T (日) (読)
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[継承]
2. (英) Hisaeda H (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Nakano Y (日) (読)
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[継承]
4. (英) Ishikawa H (日) (読)
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[継承]
5.前川 洋一
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6. (英) Ishii K (日) (読)
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[継承]
7. (英) Nitta Y (日) (読)
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[継承]
8. (英) Miyazaki J (日) (読)
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[継承]
9. (英) Himeno K (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) An interleukin-12 (IL-12) expression plasmid was transferred, using a gene gun, to mice infected with Leishmania major or Trypanosoma cruzi. Transfer of the IL-12 gene to susceptible BALB/c mice resulted in regression of lesion size and reduced the number of parasites in draining lymph nodes (LN) at the site of L. major infection. Coincident with these protective effects, the T-helper type (Th) response shifted towards Th1, as evaluated by cytokine production in vitro and L. major-specific antibody responses. Protective effects of the IL-12 gene were also observed in T. cruzi infection. Treatment of BALB/c mice infected with T. cruzi enhanced the production of interferon-gamma (IFN-gamma) by spleen cells, while suppressed production of interleukin-10 (IL-10) compared with control mice. Administration of anti-CD4 or anti-CD8 monoclonal antibody (mAb) abolished the protective immunity against T. cruzi infection, and treatment with the IL-12 gene could not restore the resistance in these mice. Mice depleted of natural killer (NK) cells with anti-asialo GM1 also became susceptible to infection, while the resistance was restored when these mice were treated with the IL-12 gene. Thus, target cells for the treatment appear to be CD4+ and CD8+ T cells, which are ordinarily activated by NK cells. These results suggest that the transfer of cytokine genes using a gene gun is an effective method for investigating the roles of cytokines and gene therapy in infectious diseases.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Biolistics (日) (読) [継承]
3. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
4. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
5. (英) Chagas Disease (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Gene Expression (日) (読) [継承]
8. (英) Gene Therapy (日) (読) [継承]
9. (英) Interleukin-12 (日) (読) [継承]
10. (英) Leishmania major (日) (読) [継承]
11. (英) Leishmaniasis, Cutaneous (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred BALB C (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15. (英) Plasmids (日) (読) [継承]
16. (英) Th1 Cells (日) (読) [継承]
17. (英) Trypanosoma cruzi (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)

ISSN (任意): 0019-2805
ISSN: 0019-2805 (pISSN: 0019-2805, eISSN: 1365-2567)
Title: Immunology
Title(ISO): Immunology
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 99 [継承]
(必須): 4 [継承]
(必須): 615 624 [継承]
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年月日 (必須): 西暦 2000年 4月 初日 (平成 12年 4月 初日) [継承]
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DOI (任意):
PMID (任意): 10792510    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Parasitology and Immunology, University of Tokushima School of Medicine, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2327200  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : T Sakai, H Hisaeda, Y Nakano, H Ishikawa, Yoichi Maekawa, K Ishii, Y Nitta, J Miyazaki and K Himeno : Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice., Immunology, Vol.99, No.4, 615-624, (発行所), (都市), April 2000.
欧文冊子 ● (種別) : T Sakai, H Hisaeda, Y Nakano, H Ishikawa, Yoichi Maekawa, K Ishii, Y Nitta, J Miyazaki and K Himeno : Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice., Immunology, Vol.99, No.4, 615-624, (発行所), (都市), April 2000.

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