『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨):
著者 (必須): 1.石澤 啓介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床薬理学])
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2.石澤 有紀 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/->個人[井澤 有紀])
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3. (英) Ohnishi Sachiyo (日) (読)
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4. (英) Motobayashi Yuki (日) (読)
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5.川添 和義
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6.濱野 修一
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7.土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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8.冨田 修平
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9.水口 和生
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10.玉置 俊晃
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題名 (必須): (英) Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Many epidemiologic studies have reported that dietary flavonoids provide protection against cardiovascular disease. Quercetin, a member of the bioflavonoids family, has been proposed to have anti-inflammatory, anti-atherogenic, and anti-hypertensive properties leading to the beneficial effects against cardiovascular diseases. Recent studies demonstrated that orally administered quercetin appeared in plasma as glucuronide-conjugated forms in rats and humans. Therefore, we examined the effect of chemically synthesized quercetin glucuronide on platelet-derived growth factor (PDGF)-induced cell migration and kinase activation in cultured rat aortic smooth muscle cells (RASMCs). PDGF-induced RASMC migration was inhibited by quercetin 3-O-beta-D-glucuronide (Q3GA). Q3GA also attenuated PDGF-induced cell proliferation in RASMCs. PDGF activated extracellular-signal regulated kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein (MAP) kinase, and Akt in RASMCs. PDGF-induced JNK and Akt activations were suppressed by Q3GA, whereas ERK1/2 and p38 MAP kinase activations were not affected. We also confirmed that PDGF-induced JNK and Akt activations were inhibited by antioxidants, N-acetylcysteine and diphenyleneiodonium chloride, in RASMCs. These findings suggest Q3GA would be an active metabolite of quercetin in plasma and may possess preventing effects for cardiovascular diseases relevant to vascular smooth muscle cell disorders.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antioxidants (日) (読) [継承]
3. (英) Cell Movement (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Glucuronides (日) (読) [継承]
7. (英) MAP Kinase Kinase 4 (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Muscle, Smooth, Vascular (日) (読) [継承]
10. (英) Platelet-Derived Growth Factor (日) (読) [継承]
11. (英) Quercetin (日) (読) [継承]
12. (英) Rats (日) (読) [継承]
13. (英) Rats, Sprague-Dawley (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Pharmacological Sciences ([日本薬理学会])
(pISSN: 1347-8613, eISSN: 1347-8648)

ISSN (任意): 1347-8613
ISSN: 1347-8613 (pISSN: 1347-8613, eISSN: 1347-8648)
Title: Journal of pharmacological sciences
Title(ISO): J Pharmacol Sci
Supplier: 公益社団法人 日本薬理学会
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 109 [継承]
(必須): 2 [継承]
(必須): 257 264 [継承]
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年月日 (必須): 西暦 2009年 2月 7日 (平成 21年 2月 7日) [継承]
URL (任意):
DOI (任意): 10.1254/jphs.08236FP    (→Scopusで検索) [継承]
PMID (任意): 19202317    (→Scopusで検索) [継承]
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WOS (任意): 000263803000014 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, Institute of Health Bioscience, University of Tokushima Graduate School, Kuramoto, Japan. ikeisuke@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Keisuke Ishizawa, Yuki Izawa-Ishizawa, Sachiyo Ohnishi, Yuki Motobayashi, Kazuyoshi Kawazoe, Shuichi Hamano, Koichiro Tsuchiya, Shuhei Tomita, Kazuo Minakuchi and Toshiaki Tamaki : Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells, Journal of Pharmacological Sciences, Vol.109, No.2, 257-264, 2009.
欧文冊子 ● Keisuke Ishizawa, Yuki Izawa-Ishizawa, Sachiyo Ohnishi, Yuki Motobayashi, Kazuyoshi Kawazoe, Shuichi Hamano, Koichiro Tsuchiya, Shuhei Tomita, Kazuo Minakuchi and Toshiaki Tamaki : Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells, Journal of Pharmacological Sciences, Vol.109, No.2, 257-264, 2009.

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