『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.石澤 啓介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床薬理学])
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2.山口 邦久 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学])
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3.堀ノ内 裕也
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4. (英) Fukuhara Yayoi (日) (読)
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[継承]
5. (英) Tajima Soichiro (日) (読)
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6.濱野 修一
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7.冨田 修平
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8.土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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9.玉置 俊晃
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題名 (必須): (英) Toward drug discovery for overcoming CKD: Development of drugs on endothelial cell protection for overcoming CKD  (日)    [継承]
副題 (任意):
要約 (任意): (英) Chronic kidney disease (CKD) is becoming a major public health problem worldwide. It is important to protect endothelial function in CKD treatment because injury of the endothelium is a critical event for the generation and progression of CKD. Recently, clinical studies showed that nifedipine, an antihypertensive drug, acts as a protective agent of endothelial cells (ECs). Nifedipine is reported to partially decompose to a nitrosonifedipine that has high reactivity against lipid-derived radicals in vitro. However, it is still unclear whether nitrosonifedipine is a biologically active agent against endothelial injury. We observed that nitrosonifedipine was converted to radical form by reaction with cultured ECs. The cumene hydroperoxide mediated cytotoxity was reduced by nitrosonifedipine in cultured human glomerular ECs (HGECs). Also nitrosonifedipine suppressed the expression of TNF-alpha-induced intercellular cell adhesion molecule-1 in HGECs. Chronic administration of N(omega)-nitro-L-arginine methyl ester (L-NAME) caused systemic arterial hypertension, endothelial injury, and renal dysfunction. In L-NAME-induced hypertensive rats, nitrosonifedipine treatment improved not only the acetylcholine-induced vasodilation of the aortic rings, but also renal dysfunction such as increasing the levels of serum creatinine and urinary protein excretion. Our preliminary data suggest that nitrosonifedipine is a new and useful drug for the treatment of CKD involving ameliorating effects on EC disorder.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Drug Discovery (日) (読) [継承]
4. (英) Endothelial Cells (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Kidney Failure, Chronic (日) (読) [継承]
7. (英) Molecular Structure (日) (読) [継承]
8. (英) Nifedipine (日) (読) [継承]
9. (英) Nitroso Compounds (日) (読) [継承]
10. (英) Vasodilator Agents (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Pharmacological Sciences ([日本薬理学会])
(pISSN: 1347-8613, eISSN: 1347-8648)

ISSN (任意): 1347-8613
ISSN: 1347-8613 (pISSN: 1347-8613, eISSN: 1347-8648)
Title: Journal of pharmacological sciences
Title(ISO): J Pharmacol Sci
Supplier: 公益社団法人 日本薬理学会
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2009年 1月 初日 (平成 21年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1254/jphs.08R08FM    (→Scopusで検索) [継承]
PMID (任意): 19151535    (→Scopusで検索) [継承]
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WOS (任意): 000262915900003 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan. ikeisuke@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
4.(英) NumberOfReferences: 30  (日)    [継承]

標準的な表示

和文冊子 ● Keisuke Ishizawa, Kunihisa Yamaguchi, Yuya Horinouchi, Yayoi Fukuhara, Soichiro Tajima, Shuichi Hamano, Shuhei Tomita, Koichiro Tsuchiya and Toshiaki Tamaki : Toward drug discovery for overcoming CKD: Development of drugs on endothelial cell protection for overcoming CKD, Journal of Pharmacological Sciences, Vol.109, No.1, 14-19, 2009.
欧文冊子 ● Keisuke Ishizawa, Kunihisa Yamaguchi, Yuya Horinouchi, Yayoi Fukuhara, Soichiro Tajima, Shuichi Hamano, Shuhei Tomita, Koichiro Tsuchiya and Toshiaki Tamaki : Toward drug discovery for overcoming CKD: Development of drugs on endothelial cell protection for overcoming CKD, Journal of Pharmacological Sciences, Vol.109, No.1, 14-19, 2009.

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