『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=193025)

EID=193025EID:193025, Map:0, LastModified:2012年8月28日(火) 20:31:15, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ueno Masaki (日) (読)
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学籍番号 (推奨):
[継承]
2.冨田 修平
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3. (英) Ueki Masaaki (日) (読)
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[継承]
4. (英) Iwanaga Yasuyuki (日) (読)
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[継承]
5. (英) Huang Cheng-Long (日) (読)
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6. (英) Onodera Masayuki (日) (読)
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7. (英) Maekawa Nobuhiro (日) (読)
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8. (英) Gonzalez J. Frank (日) (読)
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9. (英) Sakamoto Haruhiko (日) (読)
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題名 (必須): (英) Two pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1alpha-deficient mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The aim of this study was to clarify the mechanism of apoptosis seen in the cortex of neural cell-specific hypoxia inducible factor-1alpha (HIF-1alpha)-deficient embryos. A previous study showed that the neural cells in the cortical area of the mutant embryos underwent apoptosis coincident with vascular regression. Through histological, immunohistochemical, and electron microscopic technique, two kinds of apoptotic cells were detected in the mutant embryonal cortex. Apoptotic cells of one type were clustered in small round structures, 10-20 mum in diameter, whereas the others, present in large numbers, were distributed in a group at the cortical plate located more to the outer side than the round structures. The histochemical and electron microscopic findings indicate that the former represented the appearance of macrophages, in which cellular fragments including vascular cells underwent oxidative stress-related, TNF receptor-mediated, caspase-2-induced apoptosis, while the latter showed c-Myc-related, caspase-3-activated apoptosis of the neural cells. These results suggest that two pathways of apoptosis are induced in neuronal and vascular cells of the cortex in the neural cell-specific HIF-1alpha-deficient mouse.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (brain) [継承]
4. (英) Caspase 2 (日) (読) [継承]
5. (英) Caspase 3 (日) (読) [継承]
6. (英) Cerebral Cortex (日) (読) [継承]
7. (英) Hypoxia-Inducible Factor 1, alpha Subunit (日) (読) [継承]
8.免疫組織化学 (immunohistochemistry) [継承]
9. (英) In Situ Nick-End Labeling (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Microscopy, Confocal (日) (読) [継承]
12. (英) Neurons (日) (読) [継承]
13. (英) Proto-Oncogene Proteins c-myc (日) (読) [継承]
14. (英) Receptors, Tumor Necrosis Factor, Type I (日) (読) [継承]
15. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Histochemistry and Cell Biology (Society for Histochemistry)
(pISSN: 0948-6143, eISSN: 1432-119X)

ISSN (任意): 0948-6143
ISSN: 0948-6143 (pISSN: 0948-6143, eISSN: 1432-119X)
Title: Histochemistry and cell biology
Title(ISO): Histochem Cell Biol
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 125 [継承]
(必須): 5 [継承]
(必須): 535 544 [継承]
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年月日 (必須): 西暦 2005年 11月 15日 (平成 17年 11月 15日) [継承]
URL (任意):
DOI (任意): 10.1007/s00418-005-0101-1    (→Scopusで検索) [継承]
PMID (任意): 16292520    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. masaueno@med.kagawa-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masaki Ueno, Shuhei Tomita, Masaaki Ueki, Yasuyuki Iwanaga, Cheng-Long Huang, Masayuki Onodera, Nobuhiro Maekawa, Frank J. Gonzalez and Haruhiko Sakamoto : Two pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1alpha-deficient mice., Histochemistry and Cell Biology, Vol.125, No.5, 535-544, 2005.
欧文冊子 ● Masaki Ueno, Shuhei Tomita, Masaaki Ueki, Yasuyuki Iwanaga, Cheng-Long Huang, Masayuki Onodera, Nobuhiro Maekawa, Frank J. Gonzalez and Haruhiko Sakamoto : Two pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1alpha-deficient mice., Histochemistry and Cell Biology, Vol.125, No.5, 535-544, 2005.

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