『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=192816)

EID=192816EID:192816, Map:0, LastModified:2011年9月6日(火) 18:34:15, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[阪上 浩], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kitamura Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kitamura T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.阪上 浩 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学]/[徳島大学.糖尿病臨床・研究開発センター])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Maeda T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Ueno H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Nishio S (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Ohno S (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Osada i S (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Sakaue M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Ogawa W (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Kasuga M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Bacterially expressed glutathione S-transferase fusion proteins containing Rac1 were used to identify binding proteins of this Rho family GTPase present in a bovine brain extract. Five proteins of 85, 110, 125, 140 and 170 kDa were detected, all of which were associated exclusively with guanosine 5'-[gamma-thio]triphosphate-bound Rac1, not with GDP-bound Rac1. The 85 and 110 kDa proteins were identified as the regulatory and catalytic subunits respectively of phosphatidylinositol 3-kinase. Several lines of evidence suggested that the 125 kDa protein is identical with Nck-associated protein 1 (Nap1). The mobilities of the 125 kDa protein and Nap1 on SDS/PAGE were indistinguishable, and the 125 kDa protein was depleted from brain extract by preincubation with the Src homology 3 domain of Nck to which Nap1 binds. Furthermore, antibodies to Nap1 reacted with the 125 kDa protein. Nap1 was co-immunoprecipitated with a constitutively active form of Rac expressed in Chinese hamster ovary cells. The observation that complex formation between activated Rac and PAK, but not that between Rac and Nap1, could be reproduced in vitro with recombinant proteins indicates that the interaction of Nap1 with Rac is indirect. The 140 kDa Rac-binding protein is a potential candidate for a link that connects Nap1 to Rac. The multimolecular complex comprising Rac, Nap1 and probably the 140 kDa protein might mediate some of the biological effects transmitted by the multipotent GTPase.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (brain) [継承]
3. (英) Carrier Proteins (日) (読) [継承]
4. (英) Cattle (日) (読) [継承]
5. (英) Cricetinae (日) (読) [継承]
6. (英) GTP-Binding Proteins (日) (読) [継承]
7. (英) Glutathione Transferase (日) (読) [継承]
8. (英) Recombinant Fusion Proteins (日) (読) [継承]
9. (英) rac GTP-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 0264-6021
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 322 ( Pt 3) [継承]
(必須): [継承]
(必須): 873 878 [継承]
都市 (任意):
年月日 (必須): 西暦 1997年 3月 15日 (平成 9年 3月 15日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 9148763    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Second Department of Internal Medicine, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1218269  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Y Kitamura, T Kitamura, Hiroshi Sakaue, T Maeda, H Ueno, S Nishio, S Ohno, S i Osada, M Sakaue, W Ogawa and M Kasuga : Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac., The Biochemical Journal, Vol.322 ( Pt 3), 873-878, (発行所), (都市), March 1997.
欧文冊子 ● (種別) : Y Kitamura, T Kitamura, Hiroshi Sakaue, T Maeda, H Ueno, S Nishio, S Ohno, S i Osada, M Sakaue, W Ogawa and M Kasuga : Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac., The Biochemical Journal, Vol.322 ( Pt 3), 873-878, (発行所), (都市), March 1997.

関連情報

Number of session users = 0, LA = 0.72, Max(EID) = 383335, Max(EOID) = 1024622.