『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=192555EID:192555, Map:0, LastModified:2012年8月28日(火) 20:24:07, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[西田 純], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ohmori Keitaro (日) (読)
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2. (英) Luo Yuchun (日) (読)
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3. (英) Jia Yi (日) (読)
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4.西田 純
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学籍番号 (推奨):
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5. (英) Wang Zhengqi (日) (読)
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6. (英) Bunting D. Kevin (日) (読)
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7. (英) Wang Demin (日) (読)
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8. (英) Huang Hua (日) (読)
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題名 (必須): (英) IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Recent work has established important roles for basophils in regulating immune responses. To exert their biological functions, basophils need to be expanded to critical numbers. However, the mechanisms underlying basophil expansion remain unclear. In this study, we established that IL-3 played an important role in the rapid and specific expansion of basophils. We found that the IL-3 complex (IL-3 plus anti-IL-3 Ab) greatly facilitated the differentiation of GMPs into basophil lineage-restricted progenitors (BaPs) but not into eosinophil lineage-restricted progenitors or mast cells in the bone marrow. We also found that the IL-3 complex treatment resulted in approximately 4-fold increase in the number of basophil/mast cell progenitors (BMCPs) in the spleen. IL-3-driven basophil expansion depended on STAT5 signaling. We showed that GMPs but not common myeloid progenitors expressed low levels of IL-3 receptor. IL-3 receptor expression was dramatically up-regulated in BaPs but not eosinophil lineage-restricted progenitors. Approximately 38% of BMCPs expressed the IL-3R alpha-chain. The up-regulated IL-3 receptor expression was not affected by IL-3 or STAT5. Our findings demonstrate that IL-3 induced specific expansion of basophils by directing GMPs to differentiate into BaPs in the bone marrow and by increasing the number of BMCPs in the spleen.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Basophils (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Cell Lineage (日) (読) [継承]
5. (英) Gene Expression Regulation (日) (読) [継承]
6. (英) Granulocyte Precursor Cells (日) (読) [継承]
7. (英) Granulocyte-Macrophage Progenitor Cells (日) (読) [継承]
8. (英) Interleukin-3 (日) (読) [継承]
9. (英) Leukocyte Count (日) (読) [継承]
10. (英) Mast Cells (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Mice, Knockout (日) (読) [継承]
14. (英) Mice, Transgenic (日) (読) [継承]
15. (英) Myeloid Progenitor Cells (日) (読) [継承]
16. (英) Receptors, Interleukin-3 (日) (読) [継承]
17. (英) Spleen (日) (読) [継承]
18. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 182 [継承]
(必須): 5 [継承]
(必須): 2835 2841 [継承]
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年月日 (必須): 西暦 2009年 3月 1日 (平成 21年 3月 1日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0802870    (→Scopusで検索) [継承]
PMID (任意): 19234178    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, CO 80206, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Keitaro Ohmori, Yuchun Luo, Yi Jia, Jun Nishida, Zhengqi Wang, Kevin D. Bunting, Demin Wang and Hua Huang : IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen., The Journal of Immunology, Vol.182, No.5, 2835-2841, (発行所), (都市), March 2009.
欧文冊子 ● (種別) : Keitaro Ohmori, Yuchun Luo, Yi Jia, Jun Nishida, Zhengqi Wang, Kevin D. Bunting, Demin Wang and Hua Huang : IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen., The Journal of Immunology, Vol.182, No.5, 2835-2841, (発行所), (都市), March 2009.

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