『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=192522)

EID=192522EID:192522, Map:0, LastModified:2018年2月8日(木) 14:03:26, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座 (2007年4月1日〜) [継承]
著者 (必須): 1.岡村 裕彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.羽地 達次
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Negative regulation of TIMP1 is mediated by transcription factor TWIST1  (日)    [継承]
副題 (任意):
要約 (任意): (英) TWIST1 is involved in tumor invasion and metastasis by promoting epithelial-to-mesenchymal transition. However, the molecular target of TWIST1 involving this mechanism is poorly understood. To identify the TWIST1-regulated genes, we established the Saos-2 cells stably expressing TWIST1 gene by transfecting TWIST1 cDNA into the cells and performed a differential display approach by using annealing control primers. Here, we report that one of the genes that were down-regulated in TWIST1 expressing cells is predicted to be TIMP1. TIMP1 has been reported as the naturally occurring specific inhibitor of matrix metalloproteinases (MMPs). Overexpression of TWIST1 gene suppressed the expression of TIMP1 mRNA but had no effect on TIMP2 and MMP-2 expression, as determined by semi-quantitative RT-PCR. We showed that TWIST1 was up-regulated in SCCBHY cells, which have a strong capacity of invasion into mandibular bone compared with SCCHN cells. Our present results suggest that TWIST1 is involved in tumor invasion by regulating the expression of TIMP1.  (日)    [継承]
キーワード (推奨): 1. (英) Base Sequence (日) (読) [継承]
2. (英) Bone Neoplasms (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Down-Regulation (日) (読) [継承]
6. (英) Gene Expression Profiling (日) (読) [継承]
7. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Molecular Sequence Data (日) (読) [継承]
10. (英) Mouth Neoplasms (日) (読) [継承]
11. (英) Neoplasm Invasiveness (日) (読) [継承]
12. (英) Nuclear Proteins (日) (読) [継承]
13. (英) Osteosarcoma (日) (読) [継承]
14. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
15. (英) Sequence Analysis, DNA (日) (読) [継承]
16. (英) Tissue Inhibitor of Metalloproteinase-1 (日) (読) [継承]
17. (英) Transcription, Genetic (日) (読) [継承]
18. (英) Transfection (日) (読) [継承]
19. (英) Twist Transcription Factor (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1019-6439
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int J Oncol
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 35 [継承]
(必須): 1 [継承]
(必須): 181 186 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 7月 初日 (平成 21年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.3892/ijo_00000327    (→Scopusで検索) [継承]
PMID (任意): 19513566    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Histology and Oral Histology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirohiko Okamura, Kaya Yoshida and Tatsuji Haneji : Negative regulation of TIMP1 is mediated by transcription factor TWIST1, International Journal of Oncology, Vol.35, No.1, 181-186, 2009.
欧文冊子 ● Hirohiko Okamura, Kaya Yoshida and Tatsuji Haneji : Negative regulation of TIMP1 is mediated by transcription factor TWIST1, International Journal of Oncology, Vol.35, No.1, 181-186, 2009.

関連情報

Number of session users = 3, LA = 0.87, Max(EID) = 376490, Max(EOID) = 1008309.