| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Abe Masahiro (日) (読)
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| 2. | 滝口 祥令
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| 3. | (英) Ichimaru Satoshi (日) (読)
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| 4. | 土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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| 5. | (英) Wada Koichiro (日) (読)
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| ○題名 (必須): | □ | (英) Comparison of the protective effect of N-acetylcysteine by different treatments on rat myocardial ischemia-reperfusion injury. (日)
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| ○要約 (任意): | □ | (英) Reactive oxygen species have been known as important contributors to ischemia/reperfusion (I/R) injury. Studies on the beneficial effect of N-acetylcysteine (NAC), a potent antioxidant, on limiting infarct size induced by I/R yielded contrasting results. The present study was undertaken to compare the effect of NAC by different administration methods on infarct size in a rat myocardial I/R model. Rats underwent 30 min of left coronary occlusion followed by 4 h of reperfusion. Treatment with continuous infusion of NAC (150 mg/kg per hour) from 30 min before occlusion for 2 h (until 1 h after the start of reperfusion) produced a significant limitation of the infarct size as a percentage of the ischemic area (8%) compared to the non-treated control (60%). However, bolus injection of 150 mg/kg at 30 min prior to occlusion and 5 min prior to reperfusion failed to reduce it (56%) although the total dose is the same. The decreased total glutathione content and glutathione peroxidase activity in the ischemic region were recovered in the continuous infusion group, but not in the bolus injection group. The increased myeloperoxidase activity and phosphorylation of inhibitor kappaB after I/R were inhibited by the continuous treatment. These results indicate that the protective effect of NAC on myocardial infarction induced by I/R was different depending on the administration method. It is necessary to maintain blood concentration during the early period of reperfusion to obtain the beneficial effect of NAC. (日)
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| ○キーワード (推奨): | 1. | (英) Acetylcysteine (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Antioxidants (日) (読)
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| 4. | (英) Disease Models, Animal (日) (読)
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| 5. | (英) Glutathione (日) (読)
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| 6. | (英) Glutathione Peroxidase (日) (読)
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| 7. | (英) I-kappa B Proteins (日) (読)
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| 8. | (英) Infusions, Intravenous (日) (読)
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| 9. | (英) Injections, Intravenous (日) (読)
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| 10. | (英) L-Lactate Dehydrogenase (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Myocardial Reperfusion Injury (日) (読)
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| 13. | 心筋 (myocardium)
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| 14. | (英) Peroxidase (日) (読)
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| 15. | リン酸化 (phosphorylation)
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| 16. | (英) Rats (日) (読)
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| 17. | (英) Rats, Wistar (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Pharmacological Sciences ([日本薬理学会])
(pISSN: 1347-8613, eISSN: 1347-8648)
| ○ISSN (任意): | □ | 1347-8613
ISSN: 1347-8613
(pISSN: 1347-8613, eISSN: 1347-8648) Title: Journal of pharmacological sciencesTitle(ISO): J Pharmacol SciSupplier: 公益社団法人 日本薬理学会Publisher: Japanese Pharmacological Society (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 106
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 571 577
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 4月 3日 (平成 20年 4月 3日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1254/jphs.FP0071664 (→Scopusで検索)
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| ○PMID (任意): | □ | 18385540 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Clinical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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