『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=191738EID:191738, Map:0, LastModified:2018年2月9日(金) 13:26:45, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[細井 英司], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.澤田 和彦
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2.細井 英司 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.細胞・免疫解析学]/[徳島大学.医学部.保健学科.検査技術科学専攻.機能系検査学講座])
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3.坂東 美和
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4.坂田 ひろみ
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5. (英) Lee N.S. (日) (読)
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[継承]
6. (英) Jeong Y.G (日) (読)
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[継承]
7.福井 義浩
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題名 (必須): (英) Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya  (日)    [継承]
副題 (任意):
要約 (任意): (英) This study aimed to clarify changes in the spatial expressions of types 1, 2 and 3 ryanodine receptors (RyR1, RyR2 and RyR3) in the cerebellum of a Ca(2+) channel alpha(1A) subunit mutant, rolling mouse Nagoya. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) revealed that the mRNA signal levels of RyR1 and RyR3 were altered in the rolling cerebellum, which exhibited lower densities of RyR1 bands and higher densities of RyR3 bands than in the control cerebellum. Quite consistent with the RT-PCR results, the staining intensity of RyR1 and RyR3 was altered in the rolling cerebellum. RyR1 immunostaining appeared in somata and the proximal dendrites of Purkinje cells, and the staining intensity of both subcellular regions was equally lower in all cerebellar lobules of rolling mice than in those of controls. Although RyR3 immunostaining appeared in the dendrites of granule cells, more intense RyR3 staining in rolling mice than in controls was uniformly observed throughout all cerebellar lobules. The present study further examined co-localizations of ryanodine receptor subtypes and voltage-gated Ca(2+) channel alpha(1) subunits in the rolling cerebellum. Somatodendritic RyR1 immunostaining in Purkinje cells overlapped with either a mutated Ca(2+) channel alpha(1A) subunit (P/Q-type), or a Ca(2+) channel alpha(1C) subunit (L-type; dihydropyridine receptor) immunostaining. Immunostaining of these alpha(1) subunits also emerged in granule cells. Those results suggest non-region-related alterations in RyR1 and RyR3 expressions in the rolling mouse cerebellum. Such expressional changes in ryanodine receptor subtypes may be involved in Ca(2+) channel alpha(1A) subunit gene mutation, and may alter regulation of intracellular Ca(2+) concentrations in cerebellar cortical neurons.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Calcium Channels, L-Type (日) (読) [継承]
3. (英) Calcium Channels, Q-Type (日) (読) [継承]
4. (英) Calcium Signaling (日) (読) [継承]
5. (英) Cerebellar Ataxia (日) (読) [継承]
6. (英) Cerebellar Cortex (日) (読) [継承]
7. (英) Dendrites (日) (読) [継承]
8. (英) Genetic Predisposition to Disease (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Neurologic Mutants (日) (読) [継承]
12. (英) Neurons (日) (読) [継承]
13. (英) Protein Isoforms (日) (読) [継承]
14. (英) Protein Subunits (日) (読) [継承]
15. (英) Purkinje Cells (日) (読) [継承]
16. (英) RNA, Messenger (日) (読) [継承]
17. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
18. (英) Ryanodine Receptor Calcium Release Channel (日) (読) [継承]
19. (英) Synaptic Transmission (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Neuroscience ([International Brain Research Organization])
(pISSN: 0306-4522, eISSN: 1873-7544)

ISSN (任意): 0306-4522
ISSN: 0306-4522 (pISSN: 0306-4522, eISSN: 1873-7544)
Title: Neuroscience
Title(ISO): Neuroscience
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 152 [継承]
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(必須): 609 617 [継承]
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年月日 (必須): 西暦 2008年 1月 17日 (平成 20年 1月 17日) [継承]
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DOI (任意): 10.1016/j.neuroscience.2007.12.048    (→Scopusで検索) [継承]
PMID (任意): 18313230    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anatomy and Developmental Neurobiology, University of Tokushima Graduate School Institute of Health Biosciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. k-sawada@tius-hs.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuhiko Sawada, Eiji Hosoi, Miwa Bando, Hiromi Sakata-Haga, N.S. Lee, Y.G Jeong and Yoshihiro Fukui : Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya, Neuroscience, Vol.152, No.3, 609-617, 2008.
欧文冊子 ● Kazuhiko Sawada, Eiji Hosoi, Miwa Bando, Hiromi Sakata-Haga, N.S. Lee, Y.G Jeong and Yoshihiro Fukui : Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya, Neuroscience, Vol.152, No.3, 609-617, 2008.

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