『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=191545)

EID=191545EID:191545, Map:0, LastModified:2018年4月20日(金) 09:20:02, Operator:[野間 隆文], Avail:TRUE, Censor:0, Owner:[三好 圭子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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[継承]
2. (英) Nagata Hideya (日) (読)
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[継承]
3.堀口 大吾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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4.阿部 佳織
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5. (英) Arie Wahyudi Ivan (日) IVAN ARIE WAHYUDI (読) いふぁん あり わひゅでぃ
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学籍番号 (推奨): **** [ユーザ]
[継承]
6.馬場 嘉信
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学籍番号 (推奨):
[継承]
7. (英) Harada Hidemitsu (日) (読)
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[継承]
8.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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[継承]
題名 (必須): (英) BMP2-induced gene profiling in dental epithelial cell line.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (BMP2) is known as one of the inducers for tooth development. To analyze the molecular mechanisms of BMP2 on ameloblast differentiation (amelogenesis), we performed microarray analyses using rat dental epithelial cell line, HAT-7. After confirming that BMP2 could activate the canonical BMP-Smads signaling in HAT-7 cells, we analyzed the effects of BMP2 on 14,815 gene expressions and profiled them. Seventy-three genes were up-regulated and 28 genes were down-regulated by BMP2 treatment for 24 hours in HAT-7 cells. Functional classification revealed that 18% of up-regulated genes were ECM/adhesion molecules present in the enamel organ. Furthermore, we examined the expression of several differentiation markers in dental epithelial four cell-lineages including inner enamel epithelium (ameloblasts), stratum intermedium, stratum reticulum, and outer enamel epithelium. The results indicated that BMP2 might induce at least two different cell-lineage markers including a BMP antagonist expressed in HAT-7 cells, suggesting that BMP2 could accelerate amelogenesis via BMP signaling.  (日)    [継承]
キーワード (推奨): 1. (英) Ameloblasts (日) (読) [継承]
2. (英) Amelogenesis (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Base Sequence (日) (読) [継承]
5. (英) Bone Morphogenetic Protein 2 (日) (読) [継承]
6. (英) Cell Line (日) (読) [継承]
7. (英) DNA Primers (日) (読) [継承]
8. (英) Down-Regulation (日) (読) [継承]
9. (英) Epithelial Cells (日) (読) [継承]
10. (英) Gene Expression Profiling (日) (読) [継承]
11. (英) Oligonucleotide Array Sequence Analysis (日) (読) [継承]
12. (英) Rats (日) (読) [継承]
13. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
14. (英) Signal Transduction (日) (読) [継承]
15. (英) Smad Proteins (日) (読) [継承]
16. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 55 [継承]
(必須): 3-4 [継承]
(必須): 216 226 [継承]
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年月日 (必須): 西暦 2008年 8月 初日 (平成 20年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.55.216    (→Scopusで検索) [継承]
PMID (任意): 18797134    (→Scopusで検索) [継承]
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機関リポジトリ : 110862 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Biology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Keiko Miyoshi, Hideya Nagata, Taigo Horiguchi, Kaori Abe, Ivan Wahyudi Arie, Yoshinobu Baba, Hidemitsu Harada and Takafumi Noma : BMP2-induced gene profiling in dental epithelial cell line., The Journal of Medical Investigation : JMI, Vol.55, No.3-4, 216-226, 2008.
欧文冊子 ● Keiko Miyoshi, Hideya Nagata, Taigo Horiguchi, Kaori Abe, Ivan Wahyudi Arie, Yoshinobu Baba, Hidemitsu Harada and Takafumi Noma : BMP2-induced gene profiling in dental epithelial cell line., The Journal of Medical Investigation : JMI, Vol.55, No.3-4, 216-226, 2008.

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