『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ishikawa Tohru (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nakashiro Koh-ichi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Klosek K. Sebastian (日) (読)
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4. (英) Goda Hiroyuki (日) (読)
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5. (英) Hara Shingo (日) (読)
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6.内田 大亮
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学籍番号 (推奨):
[継承]
7. (英) Hamakawa Hiroyuki (日) (読)
役割 (任意):
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Hypoxia promotes the invasive and metastatic potential of tumour cells. A recent study has shown that the activation of the chemokine receptor CXCR4 by lack of oxygen in breast cancer is HIF-1-dependent. We have previously demonstrated that CXCR4 signalling is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (OSCC). In this study, we investigated a correlation between CXCR4 and HIF-1alpha expression in OSCC. Immunohistochemistry showed that CXCR4 was expressed in 20 of 85 OSCC tissues, while HIF-1alpha was expressed in 51 of 85 samples. There was a significant correlation between the expression of CXCR4 and HIF-1alpha. In human OSCC cells, hypoxia markedly enhanced the expression of both HIF-1alpha and CXCR4. Furthermore, synthetic small interfering RNA specific for HIF-1alpha significantly suppressed the expression of this protein, and also attenuated the induction of CXCR4 expression under hypoxic conditions. These results indicated that HIF-1alpha regulated hypoxia-induced CXCR4 expression in OSCC.  (日)    [継承]
キーワード (推奨): 1. (英) Blotting, Western (日) (読) [継承]
2. (英) Carcinoma, Squamous Cell (日) (読) [継承]
3. (英) Cell Hypoxia (日) (読) [継承]
4. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Hypoxia-Inducible Factor 1, alpha Subunit (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) Middle Aged (日) (読) [継承]
9. (英) Mouth Neoplasms (日) (読) [継承]
10. (英) RNA, Small Interfering (日) (読) [継承]
11. (英) Receptors, CXCR4 (日) (読) [継承]
12. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oncology Reports (Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)

ISSN (任意): 1021-335X
ISSN: 1021-335X (pISSN: 1021-335X, eISSN: 1791-2431)
Title: Oncology reports
Title(ISO): Oncol. Rep.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 21 [継承]
(必須): 3 [継承]
(必須): 707 712 [継承]
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年月日 (必須): 西暦 2009年 3月 初日 (平成 21年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.3892/or_00000275    (→Scopusで検索) [継承]
PMID (任意): 19212630    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000263584000018 [継承]
Scopus (任意): 2-s2.0-64849114878 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tohru Ishikawa, Koh-ichi Nakashiro, Sebastian K. Klosek, Hiroyuki Goda, Shingo Hara, Daisuke Uchida and Hiroyuki Hamakawa : Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma., Oncology Reports, Vol.21, No.3, 707-712, 2009.
欧文冊子 ● Tohru Ishikawa, Koh-ichi Nakashiro, Sebastian K. Klosek, Hiroyuki Goda, Shingo Hara, Daisuke Uchida and Hiroyuki Hamakawa : Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma., Oncology Reports, Vol.21, No.3, 707-712, 2009.

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