『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須):
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kawai Shigeto (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Azuma Yumiko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Fujii Etsuko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Furugaki Kou (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5.尾崎 修治
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6.松本 俊夫
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Kosaka Masaaki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Yamada-Okabe Hisafumi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models.  (日)    [継承]
副題 (任意):
要約 (任意): (英) A murine (mAHM) and a humanized (AHM) monoclonal antibody against CD317 (also called tetherin, BST2, or HM1.24 antigen), expressed preferentially in neoplastic B cells such as multiple myeloma, exhibited antitumor effects as a result of antibody-dependent cellular cytotoxicity (ADCC). The putative interferon (IFN) response elements IRF-1/2 and ISGF3 are present in the promoter of the CD317 gene, and IFN has been used for the treatment of not only myeloproliferative diseases but also solid tumors such as renal cell carcinoma (RCC) and melanoma. Therefore, we examined the effects of IFN on the expression of CD317 and on the antitumor activity of AHM and mAHM in RCC and melanoma. Flow cytometry and in vitro ADCC assays with human or mouse effector cells demonstrated that IFN-alpha markedly increased the amount of cell surface CD317 and augmented the ADCC activity of mAHM and AHM in RCC cells and to a lesser extent in melanoma cells. Administration of IFN-alpha to mice bearing RCC xenografts also increased the expression of CD317 in tumor cells. When coadministered with IFN-alpha, mAHM exhibited more profound antitumor activity in both IFN-alpha-sensitive and -insensitive RCC xenograft models. Thus, AHM in combination with IFN-alpha may be an effective therapy for the treatment of RCC.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Anti-Idiotypic (日) (読) [継承]
3. (英) Antibodies, Monoclonal (日) (読) [継承]
4. (英) Antigens, CD (日) (読) [継承]
5. (英) Carcinoma, Renal Cell (日) (読) [継承]
6. (英) Cell Line, Tumor (日) (読) [継承]
7. (英) Fluorescein-5-isothiocyanate (日) (読) [継承]
8. (英) Fluorescent Dyes (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Interferon-alpha (日) (読) [継承]
12. (英) Kidney Neoplasms (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Membrane Glycoproteins (日) (読) [継承]
15. (英) Mice (日) (読) [継承]
16. (英) Mice, Nude (日) (読) [継承]
17. (英) Mice, SCID (日) (読) [継承]
18. (英) Tumor Burden (日) (読) [継承]
19. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)

ISSN (任意): 1349-7006
ISSN: 1347-9032 (pISSN: 1347-9032, eISSN: 1349-7006)
Title: Cancer science
Title(ISO): Cancer Sci
Publisher: Wiley-Blackwell
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 99 [継承]
(必須): 12 [継承]
(必須): 2461 2466 [継承]
都市 (任意):
年月日 (必須): 西暦 2008年 11月 20日 (平成 20年 11月 20日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1349-7006.2008.00968.x    (→Scopusで検索) [継承]
PMID (任意): 19032371    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-57349089289 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Pharmaceutical Research Department, Chugai Pharmaceutical, 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Shigeto Kawai, Yumiko Azuma, Etsuko Fujii, Kou Furugaki, Shuji Ozaki, Toshio Matsumoto, Masaaki Kosaka and Hisafumi Yamada-Okabe : Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models., Cancer Science, Vol.99, No.12, 2461-2466, (発行所), (都市), Nov. 2008.
欧文冊子 ● (種別) : Shigeto Kawai, Yumiko Azuma, Etsuko Fujii, Kou Furugaki, Shuji Ozaki, Toshio Matsumoto, Masaaki Kosaka and Hisafumi Yamada-Okabe : Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models., Cancer Science, Vol.99, No.12, 2461-2466, (発行所), (都市), Nov. 2008.

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