| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Takeda Saki (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 板東 紀子
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| ○貢献度 (任意): |
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| 3. | 山西 倫太郎
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| ○貢献度 (任意): |
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| ○題名 (必須): | □ | (英) Ingested beta-carotene enhances glutathione level and up-regulates the activity of cysteine cathepsin in murine splenocytes. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) To elucidate health benefits of beta-carotene, especially on immunity, we measured redox-related indices in spleen cells from BALB/c mice supplemented with various amounts of beta-carotene. In mice supplemented with beta-carotene in their diet, glutathione, an intracellular anti-oxidation agent, increased in their splenocytes. This change was highly correlated with the accumulation of beta-carotene, but not with that of retinol. The increase in glutathione was accompanied by an increase in mRNA for gamma-glutamylcysteine synthetase, a rate-limiting enzyme for glutathione synthesis. The higher the glutathione content was in the spleen cells, the higher the activity of cysteine cathepsin became in crude antigen-presenting cells contained in the spleen. These data suggest that accumulated beta-carotene in splenocytes, without being metabolized, caused an increase in the intracellular glutathione level, thereby anti-oxidatively supporting the activity of redox-sensitive lysosomal protease, which is involved in antigen-presentation. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigen-Presenting Cells (日) (読)
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| 3. | (英) Cathepsins (日) (読)
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| 4. | (英) Cells, Cultured (日) (読)
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| 5. | (英) Cysteine (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Glutathione (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Mice, Inbred BALB C (日) (読)
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| 10. | (英) Spleen (日) (読)
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| 11. | (英) Up-Regulation (日) (読)
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| 12. | (英) beta Carotene (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Bioscience, Biotechnology, and Biochemistry ([社団法人 日本農芸化学会])
(pISSN: 0916-8451, eISSN: 1347-6947)
| ○ISSN (任意): | □ | 1347-6947
ISSN: 0916-8451
(pISSN: 0916-8451, eISSN: 1347-6947) Title: Bioscience, biotechnology, and biochemistryTitle(ISO): Biosci Biotechnol BiochemSupplier: 社団法人日本農芸化学会Publisher: Oxford University Press (NLM Catalog)
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| ○巻 (必須): | □ | 72
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 1595 1600
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 6月 7日 (平成 20年 6月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1271/bbb.80102 (→Scopusで検索)
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| ○PMID (任意): | □ | 18540097 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000257305300024
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| ○Scopus (任意): | □ | 2-s2.0-45849143974
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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