『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=191389EID:191389, Map:0, LastModified:2012年8月28日(火) 20:16:47, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[前川 洋一], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kijima Mika (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Iwata Akiko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.前川 洋一
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学籍番号 (推奨):
[継承]
4. (英) Uehara Hisanori (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Izumi Keisuke (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Kitamura Akiko (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Yagita Hideo (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Chiba Shigeru (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Shiota Hiroshi (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Yasutomo Koji (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Distinct Notch ligands possess a characteristic ability in terms of functional T cell differentiation. However, the precise role or the therapeutic potential of each Notch ligand in autoimmune diseases is largely unknown. In this study, we examined whether Jagged1 modulates a collagen-induced rheumatoid arthritis (CIA) model by altering T cell responses. The injection of a soluble Jagged1-encoding plasmid, sJag1-P, before or even after initial type II collagen (CII) immunization suppressed the disease severity of CIA. However, this treatment did not suppress CII-specific CD4(+) T cell proliferation and CII-specific Ab production. Depletion of either CD4(+) or CD8(+) T cells ameliorated CIA severity and sJag1-P further improved CIA in CD4(+) but not CD8(+) T cell-depleted mice. Injection of OVA and Jagged1-encoding plasmids inhibited proliferation of OVA-specific granzyme B-producing CD8(+) T cells, although Jagged1 could not directly inhibit CD8(+) T cell proliferation in vitro. The blockade of Jagged1 by an anti-Jagged1 Ab exacerbated CIA, whereas this effect was not observed in the absence of CD8(+) T cells. These data indicate that Jagged1 is able to deliver an indirect negative signal into CD8(+) T cells in vivo, which suggests its therapeutic potential in the treatment of CD8(+) T cell-mediated diseases, including rheumatoid arthritis.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Arthritis, Experimental (日) (読) [継承]
3. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
4. (英) Calcium-Binding Proteins (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Down-Regulation (日) (読) [継承]
8. (英) Growth Inhibitors (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Intercellular Signaling Peptides and Proteins (日) (読) [継承]
11. (英) Jurkat Cells (日) (読) [継承]
12. (英) Lymphocyte Activation (日) (読) [継承]
13. (英) Lymphocyte Depletion (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Membrane Proteins (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Mice, Inbred C57BL (日) (読) [継承]
18. (英) Mice, Inbred DBA (日) (読) [継承]
19. (英) Plasmids (日) (読) [継承]
20. (英) Signal Transduction (日) (読) [継承]
21. (英) Vaccines, DNA (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 182 [継承]
(必須): 6 [継承]
(必須): 3566 3572 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 3月 15日 (平成 21年 3月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0803765    (→Scopusで検索) [継承]
PMID (任意): 19265135    (→Scopusで検索) [継承]
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評価値 (任意):
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology and Parasitology, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Mika Kijima, Akiko Iwata, Yoichi Maekawa, Hisanori Uehara, Keisuke Izumi, Akiko Kitamura, Hideo Yagita, Shigeru Chiba, Hiroshi Shiota and Koji Yasutomo : Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells., The Journal of Immunology, Vol.182, No.6, 3566-3572, (発行所), (都市), March 2009.
欧文冊子 ● (種別) : Mika Kijima, Akiko Iwata, Yoichi Maekawa, Hisanori Uehara, Keisuke Izumi, Akiko Kitamura, Hideo Yagita, Shigeru Chiba, Hiroshi Shiota and Koji Yasutomo : Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells., The Journal of Immunology, Vol.182, No.6, 3566-3572, (発行所), (都市), March 2009.

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