| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Liu Pu (日) (読)
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| 2. | (英) Yao Zhi (日) (読)
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| 3. | (英) Zhang Wen (日) (読)
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| 4. | 高石 喜久
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| 5. | (英) Duan Hong-Quan (日) (読)
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| ○題名 (必須): | □ | (英) Novel Nortriterpenes from Phlomis umbrosa. (日)
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| ○要約 (任意): | □ | (英) We isolated 8 novel 28-noroleanane-derived spirocyclic triterpenoids with unusual skeleton structures, phlomisone (1), phlomistetraol A (2), phlomistetraol B (3), phlomistetraol C (4), phlomispentaol (5), phlomishexaol A (6), phlomishexaol B (7), and phlomisin (8), from the ethanol extract of Phlomis umbrosa rhizomes. Their structures were elucidated on the basis of spectroscopic methods, including 1D, 2D nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), and X-ray analyses. Compounds 1-3, 5, and 7 exhibited positive cytotoxic activities against the carcinoma cell lines Hela and L929 in vitro, and these bioactive data suggested that the C-18 and C-21 positions had oxygenated functions that can improve the activity of the compound. (日)
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| ○キーワード (推奨): | 1. | (英) Antineoplastic Agents, Phytogenic (日) (読)
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| 2. | (英) Cell Line, Tumor (日) (読)
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| 3. | (英) Humans (日) (読)
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| 4. | (英) Magnetic Resonance Spectroscopy (日) (読)
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| 5. | 質量分析法 (mass spectrometry)
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| 6. | (英) Phlomis (日) (読)
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| 7. | (英) Triterpenes (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Chemical & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0009-2363, eISSN: 1347-5223)
| ○ISSN (任意): | □ | 0009-2363
ISSN: 0009-2363
(pISSN: 0009-2363, eISSN: 1347-5223) Title: Chemical & pharmaceutical bulletinTitle(ISO): Chem Pharm Bull (Tokyo)Supplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
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| ○巻 (必須): | □ | 56
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 951 955
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 7月 初日 (平成 20年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/cpb.56.951 (→Scopusで検索)
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| ○PMID (任意): | □ | 18591808 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000258180000014
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| ○Scopus (任意): | 1. | 2-s2.0-46749129377
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| ○備考 (任意): | 1. | (英) Article.Affiliation: School of Pharmaceutical Science, Basic Medical Research Center of Tianjin, Tianjin Medical University, Tianjin, China. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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