『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=190960EID:190960, Map:0, LastModified:2017年12月16日(土) 22:21:01, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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4.中江 英明
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5.松尾 敬志
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題名 (必須): (英) Human gingival fibroblasts express functional chemokine receptor CXCR6.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have reported that CXCL16, a recently discovered transmembrane chemokine, is expressed in human gingival fibroblasts (HGF). However, it is not known whether HGF express CXCR6, the receptor for CXCL16, or CXCL16 affects HGF biology. We have shown that HGF expressed CXCR6 by reverse transcription-polymerase chain reaction and flow cytometric analysis. Moreover, we elucidated that tumour necrosis factor (TNF)-alpha and cytosine-guanine dinucleotide (CpG) DNA (Toll-like receptor-9 ligand) treatment enhanced CXCR6 expression by HGF. Interleukin (IL)-4, IL-13 and CpG DNA up-regulated CXCR6 expression by TNF-alpha-stimulated HGF. On the other hand, IL-1beta and interferon-gamma inhibited CXCR6 expression on TNF-alpha-treated HGF. CXCL16 treatment induced HGF proliferation and phosphorylation of extracellular regulated kinase (ERK) and protein kinase B (AKT) in HGF. In conclusion, HGF expressed CXCR6 functionally, because CXCL16 induced HGF proliferation and ERK and AKT phosphorylation in HGF. These results indicate that CXCL16 may play an important role in the pathogenesis and remodelling in periodontally diseased tissues.  (日)    [継承]
キーワード (推奨): 1. (英) Cell Proliferation (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Chemokines, CXC (日) (読) [継承]
4. (英) CpG Islands (日) (読) [継承]
5. (英) Cytokines (日) (読) [継承]
6. (英) Extracellular Signal-Regulated MAP Kinases (日) (読) [継承]
7. (英) Fibroblasts (日) (読) [継承]
8. (英) Gingiva (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Ligands (日) (読) [継承]
11. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
12. (英) Receptors, Chemokine (日) (読) [継承]
13. (英) Receptors, Scavenger (日) (読) [継承]
14. (英) Receptors, Virus (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
16. (英) Toll-Like Receptors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2009年 6月 初日 (平成 21年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2009.03915.x    (→Scopusで検索) [継承]
PMID (任意): 19438592    (→Scopusで検索) [継承]
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WOS (任意): 000265883400005 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Departments of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2691968  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : Human gingival fibroblasts express functional chemokine receptor CXCR6., Clinical and Experimental Immunology, Vol.156, No.3, 413-418, 2009.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : Human gingival fibroblasts express functional chemokine receptor CXCR6., Clinical and Experimental Immunology, Vol.156, No.3, 413-418, 2009.

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