『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日) [継承]
2.広島大学 [継承]
著者 (必須): 1. (英) Lin YY (日) Yu-Yu Lin (読)
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[継承]
2. (英) Tanaka Nobuaki (日) (読)
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[継承]
3. (英) Ohkuma Satoru (日) (読)
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[継承]
4. (英) Kamiya Takashi (日) (読)
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[継承]
5. (英) Kunimatsu Ryo (日) (読)
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[継承]
6. (英) Huang Y-C (日) YU-CHING HUANG (読)
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[継承]
7. (英) Yoshioka Motoko (日) (読)
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[継承]
8. (英) Mitsuyoshi Tomomi (日) (読)
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[継承]
9. (英) Tanne Yuki (日) (読)
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[継承]
10.谷本 幸太郎 ([広島大学])
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[継承]
11.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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[継承]
12.丹根 一夫 ([広島大学])
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[継承]
題名 (必須): (英) The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading  (日)    [継承]
副題 (任意):
要約 (任意): (英) Osteoarthritis (OA) in the temporomandibular joint (TMJ) is a degenerative disease caused by excessive external loading. Recently, it was reported that the damage in the mineralized subchondral bone caused by traumatic impact-loading is responsible for the initiation and progression of cartilage degeneration. Thus far, we have hypothesized that cytokines released from damaged subchondral bone from impact-loading affect the cartilage catabolism under pathological conditions. An impactor of 200 gw was dropped onto the top of a porcine mandibular condyle. After organ culture for 2 days, we investigated the association between the subchondral bone and cartilage using histological and biochemical experiments. The impact-loading induced the expression of IL-1beta immunohistochemically and prominently up-regulated IL-1alpha and IL-1beta mRNA levels in subchondral bone. We confirmed a significant decrease in type II collagen and aggrecan mRNA expressions in chondrocytes by co-culture with osteoblasts after impact-loading, and significant increase in mRNA and protein expressions of IL-1beta in subchondral osteoblasts from impact-loaded subchondral bone. The mRNA expressions of type II collagen, aggrecan, and type X collagen in chondrocytes were decreased significantly by the co-culture with osteoblasts pre-treated by IL-1beta, -6, and TNF-alpha. Among them, osteoblasts pre-treated by IL-1beta affected chondrocytes most strongly. It was also shown that IL-1beta-treated osteoblasts enhanced the MMP-1 mRNA level most markedly in chondrocytes among the four cytokines. These results suggest that the TMJ subjected to impact-loading can increase directly IL-1beta synthesis in the subchondral region, subsequently altering the metabolism of adjacent cartilage and may eventually resulting in the onset and progression of TMJ-OA.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cartilage (日) (読) [継承]
3. (英) Cytokines (日) (読) [継承]
4. (英) Interleukin-1beta (日) (読) [継承]
5. (英) Mandible (日) (読) [継承]
6. (英) Organ Culture Techniques (日) (読) [継承]
7. (英) Swine (日) (読) [継承]
8. (英) Weight-Bearing (日) (読) [継承]
9. (英) Wounds, Nonpenetrating (日) (読) [継承]
発行所 (推奨): Springer-Verlag [継承]
誌名 (必須): Annals of Biomedical Engineering (Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)

ISSN (任意): 1573-9686
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 37 [継承]
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(必須): 1358 1367 [継承]
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年月日 (必須): 西暦 2009年 7月 末日 (平成 21年 7月 末日) [継承]
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DOI (任意): 10.1007/s10439-009-9696-z    (→Scopusで検索) [継承]
PMID (任意): 19381811    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● YY Lin, Nobuaki Tanaka, Satoru Ohkuma, Takashi Kamiya, Ryo Kunimatsu, Y-C Huang, Motoko Yoshioka, Tomomi Mitsuyoshi, Yuki Tanne, Kotaro Tanimoto, Eiji Tanaka and Kazuo Tanne : The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading, Annals of Biomedical Engineering, Vol.37, No.7, 1358-1367, 2009.
欧文冊子 ● YY Lin, Nobuaki Tanaka, Satoru Ohkuma, Takashi Kamiya, Ryo Kunimatsu, Y-C Huang, Motoko Yoshioka, Tomomi Mitsuyoshi, Yuki Tanne, Kotaro Tanimoto, Eiji Tanaka and Kazuo Tanne : The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading, Annals of Biomedical Engineering, Vol.37, No.7, 1358-1367, 2009.

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