『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日) [継承]
2.広島大学 [継承]
著者 (必須): 1.谷本 幸太郎 ([広島大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kitamura R (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Tanne Y (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Kamiya T (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kunimatsu R (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Yoshioka M (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Tanaka N (日) (読)
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学籍番号 (推奨):
[継承]
8.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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学籍番号 (推奨):
[継承]
9.丹根 一夫 ([広島大学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli  (日)    [継承]
副題 (任意):
要約 (任意): (英)   (日) Hyaluronan (HA) is a component of the extracellular matrices of cartilage contributing to the structural and functional integrity. HA metabolism is regulated by both anabolic and catabolic processes; however, a great deal more of the detail has been unknown yet. The purpose of this study was to clarify the effect of excessive mechanical load on the expression and activity of hyaluronidase (HYAL) in chondrocytes with a special reference to the expressions of IL-1beta and tumor necrosis factor (TNF)-alpha. A cyclic tensile load of 22.8% cell elongation, regarded as an excessive mechanical stimulus, was applied to cultured rabbit knee articular chondrocytes. HYAL1, HYAL2, IL-1beta, and TNF-alpha mRNA levels were examined by quantitative real-time PCR analysis. The HYAL activity in culture medium was examined by HA zymography. Both HYAL1 and HYAL2 mRNA levels were upregulated significantly by the loading in cultured chondrocytes. HYAL activity was also enhanced as compared with unloaded controls. The IL-1beta mRNA level was upregulated significantly by the loading, and TNF-alpha mRNA level was slightly upregulated. HYAL1 and HYAL2 mRNA levels were upregulated significantly by IL-1beta treatment, resulting in a slight increase in HYAL activity. These results show that the expression of HYAL1 and HYAL2 in articular chondrocytes is enhanced by excessive mechanical stimuli and affected in part by induction of IL-1beta, leading to HA catabolism in articular cartilage. (c) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2009.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Chondrocytes (日) (読) [継承]
4. (英) Gene Expression Regulation (日) (読) [継承]
5. (英) Hyaluronic Acid (日) (読) [継承]
6. (英) Hyaluronoglucosaminidase (日) (読) [継承]
7. (英) Inflammation Mediators (日) (読) [継承]
8. (英) Interleukin-1beta (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) RNA, Messenger (日) (読) [継承]
11. (英) Rabbits (日) (読) [継承]
12. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
13. (英) Stress, Mechanical (日) (読) [継承]
14. (英) Tensile Strength (日) (読) [継承]
15. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Biomedical Materials Research. Part A ([John Wiley & Sons, Inc.])
(pISSN: 1549-3296, eISSN: 1552-4965)

ISSN (任意): 1552-4965
ISSN: 1549-3296 (pISSN: 1549-3296, eISSN: 1552-4965)
Title: Journal of biomedical materials research. Part A
Title(ISO): J Biomed Mater Res A
Supplier: Society for Biomaterials
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 373 380 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 4月 末日 (平成 22年 4月 末日) [継承]
URL (任意):
DOI (任意): 10.1002/jbm.a.32540    (→Scopusで検索) [継承]
PMID (任意): 19569218    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University, Minami-Ku, Hiroshima 734-8553, Japan. tkotaro@hiroshima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kotaro Tanimoto, R Kitamura, Y Tanne, T Kamiya, R Kunimatsu, M Yoshioka, N Tanaka, Eiji Tanaka and Kazuo Tanne : Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli, Journal of Biomedical Materials Research. Part A, Vol.93, No.1, 373-380, 2010.
欧文冊子 ● Kotaro Tanimoto, R Kitamura, Y Tanne, T Kamiya, R Kunimatsu, M Yoshioka, N Tanaka, Eiji Tanaka and Kazuo Tanne : Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli, Journal of Biomedical Materials Research. Part A, Vol.93, No.1, 373-380, 2010.

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