| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 片岡 宏介 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健福祉学]/徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.歯学系.予防歯学令和6年4月より併任)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) McGhee R. Jerry (日) (読)
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| ○学籍番号 (推奨): |
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| 3. | (英) Kobayashi Ryoki (日) (読)
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| ○学籍番号 (推奨): |
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| 4. | (英) Fujihashi Keiko (日) (読)
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| 5. | (英) Shizukuishi Satoshi (日) (読)
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| 6. | (英) Fujihashi Kohtaro (日) (読)
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| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Nasal Flt3 ligand cDNA elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Nasal immunization is an effective way to induce both mucosal and systemic immune responses. In this study, we assessed a cDNA vector for Flt3 ligand (FL) for its potential to enhance mucosal immunity or tolerance. Interestingly, tolerance was avoided and elevated levels of OVA-specific Ab responses were induced in nasal washes, fecal extracts, and saliva as well as in plasma when compared with mice given nasal OVA plus DNA plasmid without the FL gene. In addition, significant levels of OVA-specific CD4+ T cell proliferative responses and OVA-induced IL-4 and IL-2 production were noted in spleen and cervical lymph nodes. Further, marked increases in FL protein occurred in the nasal lamina propria and submandibular glands and the frequencies of CD11c+CD8+ dendritic cells (DCs) significantly increased in the mucosal tissues. Moreover, these DCs expressed high levels of CD40, CD80, CD86, and MHC class II molecules. Nasal delivery of plasmid FL with OVA resulted in FL expression in both mucosal inductive and effector sites and resulted in expanded activated lymphoid DCs. Thus, nasal plasmid FL prevents mucosal tolerance and enhances active immunity when given by a mucosal route. (日)
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| ○キーワード (推奨): | 1. | (英) Adjuvants, Immunologic (日) (読)
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| 2. | (英) Administration, Intranasal (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Antigens, CD11c (日) (読)
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| 5. | (英) Antigens, CD8 (日) (読)
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| 6. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 7. | 細胞分裂 (cell division)
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| 8. | 細胞質分裂 (cytokinesis)
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| 9. | (英) DNA, Complementary (日) (読)
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| 10. | (英) Dendritic Cells (日) (読)
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| 11. | (英) Epitopes, T-Lymphocyte (日) (読)
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| 12. | (英) Female (日) (読)
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| 13. | (英) Genetic Vectors (日) (読)
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| 14. | (英) Immunity, Mucosal (日) (読)
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| 15. | (英) Immunoglobulin A (日) (読)
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| 16. | (英) Ligands (日) (読)
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| 17. | (英) Membrane Proteins (日) (読)
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| 18. | (英) Mice (日) (読)
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| 19. | (英) Mice, Inbred C57BL (日) (読)
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| 20. | (英) Nasal Mucosa (日) (読)
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| 21. | (英) Ovalbumin (日) (読)
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| 22. | (英) Vaccines, DNA (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 0022-1767
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 172
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 3612 3619
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 3月 15日 (平成 16年 3月 15日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 15004163 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000220096000033
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Oral Biology, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S. (日)
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