『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kobayashi Ryoki (日) (読)
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[継承]
2. (英) Kohda Tomoko (日) (読)
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[継承]
3.片岡 宏介
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学籍番号 (推奨):
[継承]
4. (英) Ihara Hideshi (日) (読)
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[継承]
5. (英) Kozaki Shunji (日) (読)
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[継承]
6. (英) Pascual W. David (日) (読)
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[継承]
7. (英) Staats F. Herman (日) (読)
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[継承]
8. (英) Kiyono Hiroshi (日) (読)
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[継承]
9. (英) McGhee R. Jerry (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Fujihashi Kohtaro (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) A novel neurotoxoid vaccine prevents mucosal botulism.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The threat posed by botulism, classically a food- and waterborne disease with a high morbidity and mortality, has increased exponentially in an age of bioterrorism. Because botulinum neurotoxin (BoNT) could be easily disseminated by terrorists using an aerosol or could be used to contaminate the food or water supply, the Centers for Disease Control and Prevention and the National Institute of Allergy and Infectious Diseases has classified it as a category A agent. Although clearly the development of a safe and effective mucosal vaccine against this toxin should be a high priority, essentially no studies to date have assessed mucosal immune responses to this disease. To bridge this gap in our knowledge, we immunized mice weekly for 4 wk with nasal doses of BoNT type A toxoid and a mutant of cholera toxin termed E112K. We found elevated levels of BoNT-specific IgG Abs in plasma and of secretory IgA Abs in external secretions (nasal washes, saliva, and fecal extracts). When mice given nasal BoNT vaccine were challenged with 4 x 10(3) LD50 of BoNT type A (BoNT/A) via the i.p. route, complete protection was seen, while naive mice given the same dosage died within 2 h. To further confirm the efficacy of this nasal BoNT vaccine, an oral LD50 was determined. When mice were given an oral challenge of 5 microg (2 x oral LD50) of progenitor BoNT/A, all immunized mice survived beyond 5 days, while nonimmunized mice did not. The fecal extract samples from nasally vaccinated mice were found to contain neutralizing secretory IgA Abs. Taken together, these results show that nasal BoNT/A vaccine effectively prevents mucosal BoNT intoxication.  (日)    [継承]
キーワード (推奨): 1. (英) Adjuvants, Immunologic (日) (読) [継承]
2. (英) Administration, Intranasal (日) (読) [継承]
3. (英) Administration, Oral (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Antibodies, Bacterial (日) (読) [継承]
6. (英) Antibody-Producing Cells (日) (読) [継承]
7. (英) Bacterial Vaccines (日) (読) [継承]
8. (英) Botulinum Toxin Type A (日) (読) [継承]
9. (英) Botulism (日) (読) [継承]
10. (英) Clostridium botulinum type A (日) (読) [継承]
11. (英) Immunity, Innate (日) (読) [継承]
12. (英) Immunoglobulin A, Secretory (日) (読) [継承]
13. (英) Intestinal Mucosa (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred C57BL (日) (読) [継承]
16. (英) Nasal Mucosa (日) (読) [継承]
17. (英) Toxoids (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J. Immunol.
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 2190 2195 [継承]
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年月日 (必須): 西暦 2005年 2月 15日 (平成 17年 2月 15日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 15699151    (→Scopusで検索) [継承]
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WOS (任意): 000226986700050 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pediatric Dentistry, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Ryoki Kobayashi, Tomoko Kohda, Kosuke Kataoka, Hideshi Ihara, Shunji Kozaki, David W. Pascual, Herman F. Staats, Hiroshi Kiyono, Jerry R. McGhee and Kohtaro Fujihashi : A novel neurotoxoid vaccine prevents mucosal botulism., The Journal of Immunology, Vol.174, No.4, 2190-2195, 2005.
欧文冊子 ● Ryoki Kobayashi, Tomoko Kohda, Kosuke Kataoka, Hideshi Ihara, Shunji Kozaki, David W. Pascual, Herman F. Staats, Hiroshi Kiyono, Jerry R. McGhee and Kohtaro Fujihashi : A novel neurotoxoid vaccine prevents mucosal botulism., The Journal of Immunology, Vol.174, No.4, 2190-2195, 2005.

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