| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hino Ayako (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Fukuyama Satoshi (日) (読)
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| 3. | 片岡 宏介 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健福祉学]/徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.歯学系.予防歯学令和6年4月より併任)
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| 4. | (英) Kweon Mi-Na (日) (読)
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| 5. | (英) Fujihashi Kohtaro (日) (読)
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| [継承] |
| 6. | (英) Kiyono Hiroshi (日) (読)
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| ○貢献度 (任意): |
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| ○題名 (必須): | □ | (英) Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) OVA-induced allergic diarrhea occurs as a consequence of over-expression of Th1 inhibitory IL-12p40 monomers and homodimers in the large intestine, establishing a dominant Th2-type environment. In this study, we demonstrate that intranasally administered murine IL-12p70 naked DNA expression plasmids resulted in the synthesis of corresponding cytokine in the large intestinal CD11c(+) dendritic cells, leading to the inhibition of Ag-specific Th2-type response for the prevention of allergic diarrhea and the suppression of clinical symptoms including OVA-specific IgE Ab synthesis. The nasal IL-12p70 DNA treatment proved effective even after the establishment of allergic diarrhea. These results suggest that the mucosal administration of naked IL-12p70 DNA plasmid should be considered as a possible preventive and therapeutic treatment for Th2 cell-mediated food allergic diseases in the intestinal tract. (日)
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| ○キーワード (推奨): | 1. | (英) Administration, Intranasal (日) (読)
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| 2. | (英) Colitis (日) (読)
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| 3. | 細胞質分裂 (cytokinesis)
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| 4. | (英) Diarrhea (日) (読)
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| 5. | (英) Down-Regulation (日) (読)
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| 6. | 遺伝子治療 (gene therapy)
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| 7. | (英) Green Fluorescent Proteins (日) (読)
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| 8. | (英) Immunoglobulin A (日) (読)
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| 9. | (英) Immunoglobulin G (日) (読)
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| 10. | (英) Interleukin-12 (日) (読)
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| 11. | (英) Intestine, Large (日) (読)
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| 12. | (英) Lymphoid Tissue (日) (読)
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| 13. | (英) Nasopharynx (日) (読)
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| 14. | (英) Ovalbumin (日) (読)
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| 15. | (英) Plasmids (日) (読)
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| 16. | (英) Protein Subunits (日) (読)
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| 17. | (英) Spleen (日) (読)
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| 18. | (英) Th2 Cells (日) (読)
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| 19. | (英) Vaccines, DNA (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 0022-1767
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 174
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 7423 7432
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 6月 1日 (平成 17年 6月 1日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 15905591 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000229298400106
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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