『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
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○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Kobayashi Shu (日) (読)
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[継承]
2. (英) Ikari Katsunori (日) (読)
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[継承]
3. (英) Kaneko Hirotaka (日) (読)
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[継承]
4. (英) Kochi Yuta (日) (読)
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5. (英) Yamamoto Kazuhiko (日) (読)
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6. (英) Shimane Kenichi (日) (読)
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7. (英) Nakamura Yusuke (日) (読)
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8. (英) Toyama Yoshiaki (日) (読)
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9. (英) Mochizuki Takeshi (日) (読)
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10. (英) Tsukahara So (日) (読)
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11. (英) Kawaguchi Yasushi (日) (読)
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12. (英) Terai Chihiro (日) (読)
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13. (英) Hara Masako (日) (読)
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14. (英) Tomatsu Taisuke (日) (読)
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15. (英) Yamanaka Hisashi (日) (読)
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16. (英) Horiuchi Takahiko (日) (読)
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17. (英) Tao Kayoko (日) (読)
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18.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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19. (英) Hamada Daisuke (日) (読)
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20.安井 夏生
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21.井上 寛
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22.板倉 光夫
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23. (英) Okamoto Hiroshi (日) (読)
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24.鎌谷 直之 ([徳島大学.ゲノム機能研究センター])
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25. (英) Momohara Shigeki (日) (読)
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○題名 (必須): □(英) Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) OBJECTIVE: STAT4 encodes a transcriptional factor that transmits signals induced by several key cytokines, and it might be a key molecule in the development of autoimmune diseases. Recently, a STAT4 haplotype was reported to be associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in Caucasian populations. This was replicated in a Korean RA population. Interestingly, the degree of risk of RA susceptibility with the STAT4 haplotype was similar in the Caucasian and Korean populations. The present study was undertaken to investigate the effect of STAT4 on susceptibility to RA and SLE in the Japanese. METHODS: We performed an association study using 3 independent Japanese RA case-control populations (total 3,567 cases and 2,199 controls) and 3 independent Japanese SLE populations (total 591 cases). All samples were genotyped using the TaqMan fluorogenic 5' nuclease assay for single-nucleotide polymorphism (SNP) rs7574865, which tags the susceptibility haplotype. The association of the SNP with disease susceptibility in each case-control study was calculated using Fisher's exact test, and the results were combined, using the Mantel-Haenszel method, to obtain combined odds ratios (ORs). RESULTS: We observed a significant association of the STAT4 polymorphism with susceptibility to both RA and SLE. The combined ORs for RA and SLE, respectively, were 1.27 (P = 8.4 x 10(-9)) and 1.61 (P = 2.1 x 10(-11)) for allele frequency distribution; these ORs were quite similar to those previously observed in the Caucasian population. CONCLUSION: We conclude that STAT4 is associated with RA and SLE in the Japanese. Our results indicate that STAT4 is a common genetic risk factor for autoimmune diseases, with similar strength across major racial groups.  (日)    [継承]
○キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Arthritis, Rheumatoid (日) (読) [継承]
3. (英) Case-Control Studies (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Genetic Predisposition to Disease (日) (読) [継承]
6. (英) Haplotypes (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Japan (日) (読) [継承]
9. (英) Lupus Erythematosus, Systemic (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Polymorphism, Single Nucleotide (日) (読) [継承]
13. (英) Risk Factors (日) (読) [継承]
14. (英) STAT4 Transcription Factor (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Arthritis and Rheumatism (American Rheumatism Association/Arthritis Foundation/American Rheumatism Association/American College of Rheumatology)
(pISSN: 0004-3591, eISSN: 1529-0131)

○ISSN (任意): □0004-3591
ISSN: 0004-3591 (pISSN: 0004-3591, eISSN: 1529-0131)
Title: Arthritis and rheumatism
Title(ISO): Arthritis Rheum
Publisher: John Wiley & Sons Inc.
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □58 [継承]
○号 (必須): □7 [継承]
○頁 (必須): □1940 1946 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2008年 7月 初日 (平成 20年 7月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1002/art.23494    (→Scopusで検索) [継承]
○PMID (任意): □18576330    (→Scopusで検索) [継承]
○CRID (任意):
○WOS (任意): □000257469800008 [継承]
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○備考 (任意): 1.(英) Article.Affiliation: Tokyo Women's Medical University, Tokyo, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shu Kobayashi, Katsunori Ikari, Hirotaka Kaneko, Yuta Kochi, Kazuhiko Yamamoto, Kenichi Shimane, Yusuke Nakamura, Yoshiaki Toyama, Takeshi Mochizuki, So Tsukahara, Yasushi Kawaguchi, Chihiro Terai, Masako Hara, Taisuke Tomatsu, Hisashi Yamanaka, Takahiko Horiuchi, Kayoko Tao, Koji Yasutomo, Daisuke Hamada, Natsuo Yasui, Hiroshi Inoue, Mitsuo Itakura, Hiroshi Okamoto, Naoyuki Kamatani and Shigeki Momohara : Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population., Arthritis and Rheumatism, Vol.58, No.7, 1940-1946, 2008.
欧文冊子 ● Shu Kobayashi, Katsunori Ikari, Hirotaka Kaneko, Yuta Kochi, Kazuhiko Yamamoto, Kenichi Shimane, Yusuke Nakamura, Yoshiaki Toyama, Takeshi Mochizuki, So Tsukahara, Yasushi Kawaguchi, Chihiro Terai, Masako Hara, Taisuke Tomatsu, Hisashi Yamanaka, Takahiko Horiuchi, Kayoko Tao, Koji Yasutomo, Daisuke Hamada, Natsuo Yasui, Hiroshi Inoue, Mitsuo Itakura, Hiroshi Okamoto, Naoyuki Kamatani and Shigeki Momohara : Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population., Arthritis and Rheumatism, Vol.58, No.7, 1940-1946, 2008.

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