『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=189901EID:189901, Map:0, LastModified:2012年10月9日(火) 18:29:38, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐々木 卓也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yamamura Rie (日) (読)
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2.西村 範行
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3.中逵 弘能
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4.荒瀬 誠治
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5.佐々木 卓也 ([徳島大学])
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題名 (必須): (英) The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions.  (日)    [継承]
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要約 (任意): (英) The assembly of tight junctions (TJs) and adherens junctions (AJs) is regulated by the transport of integral TJ and AJ proteins to and/or from the plasma membrane (PM) and it is tightly coordinated in epithelial cells. We previously reported that Rab13 and a junctional Rab13-binding protein (JRAB)/molecule interacting with CasL-like 2 (MICAL-L2) mediated the endocytic recycling of an integral TJ protein occludin and the formation of functional TJs. Here, we investigated the role of Rab13 and JRAB/MICAL-L2 in the transport of other integral TJ and AJ proteins claudin-1 and E-cadherin to the PM by using a Ca(2+)-switch model. Although knockdown of Rab13 specifically suppressed claudin-1 and occludin but not E-cadherin transport, knockdown of JRAB/MICAL-L2 and expression of its Rab13-binding domain (JRAB/MICAL-L2-C) inhibited claudin-1, occludin, and E-cadherin transport. We then identified Rab8 as another JRAB/MICAL-L2-C-binding protein. Knockdown of Rab8 inhibited the Rab13-independent transport of E-cadherin to the PM. Rab8 and Rab13 competed with each other for the binding to JRAB/MICAL-L2 and functionally associated with JRAB/MICAL-L2 at the perinuclear recycling/storage compartments and PM, respectively. These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of AJs and TJs.  (日)    [継承]
キーワード (推奨): 1. (英) Adherens Junctions (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Binding, Competitive (日) (読) [継承]
4. (英) Cadherins (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Cytoskeletal Proteins (日) (読) [継承]
7. (英) Endocytosis (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Intracellular Space (日) (読) [継承]
10. (英) Membrane Proteins (日) (読) [継承]
11. (英) Models, Biological (日) (読) [継承]
12. (英) Protein Binding (日) (読) [継承]
13. (英) Protein Structure, Tertiary (日) (読) [継承]
14. (英) Protein Transport (日) (読) [継承]
15. (英) Tight Junctions (日) (読) [継承]
16. (英) rab GTP-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Biology of the Cell (The American Society for Cell Biology)
(pISSN: 1059-1524, eISSN: 1939-4586)

ISSN (任意): 1939-4586
ISSN: 1059-1524 (pISSN: 1059-1524, eISSN: 1939-4586)
Title: Molecular biology of the cell
Title(ISO): Mol Biol Cell
Publisher: American Society for Cell Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 971 983 [継承]
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年月日 (必須): 西暦 2008年 3月 初日 (平成 20年 3月 初日) [継承]
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DOI (任意): 10.1091/mbc.E07-06-0551    (→Scopusで検索) [継承]
PMID (任意): 18094055    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2262956  (日)    [継承]

標準的な表示

和文冊子 ● Rie Yamamura, Noriyuki Nishimura, Hiroyoshi Nakatsuji, Seiji Arase and Takuya Sasaki : The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions., Molecular Biology of the Cell, Vol.19, No.3, 971-983, 2008.
欧文冊子 ● Rie Yamamura, Noriyuki Nishimura, Hiroyoshi Nakatsuji, Seiji Arase and Takuya Sasaki : The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions., Molecular Biology of the Cell, Vol.19, No.3, 971-983, 2008.

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