| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yamamura Rie (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 西村 範行
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| 3. | 中逵 弘能
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 荒瀬 誠治
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| 5. | 佐々木 卓也 ([徳島大学])
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| ○題名 (必須): | □ | (英) The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The assembly of tight junctions (TJs) and adherens junctions (AJs) is regulated by the transport of integral TJ and AJ proteins to and/or from the plasma membrane (PM) and it is tightly coordinated in epithelial cells. We previously reported that Rab13 and a junctional Rab13-binding protein (JRAB)/molecule interacting with CasL-like 2 (MICAL-L2) mediated the endocytic recycling of an integral TJ protein occludin and the formation of functional TJs. Here, we investigated the role of Rab13 and JRAB/MICAL-L2 in the transport of other integral TJ and AJ proteins claudin-1 and E-cadherin to the PM by using a Ca(2+)-switch model. Although knockdown of Rab13 specifically suppressed claudin-1 and occludin but not E-cadherin transport, knockdown of JRAB/MICAL-L2 and expression of its Rab13-binding domain (JRAB/MICAL-L2-C) inhibited claudin-1, occludin, and E-cadherin transport. We then identified Rab8 as another JRAB/MICAL-L2-C-binding protein. Knockdown of Rab8 inhibited the Rab13-independent transport of E-cadherin to the PM. Rab8 and Rab13 competed with each other for the binding to JRAB/MICAL-L2 and functionally associated with JRAB/MICAL-L2 at the perinuclear recycling/storage compartments and PM, respectively. These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of AJs and TJs. (日)
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| ○キーワード (推奨): | 1. | (英) Adherens Junctions (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Binding, Competitive (日) (読)
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| 4. | (英) Cadherins (日) (読)
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| 5. | (英) Cell Line (日) (読)
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| 6. | (英) Cytoskeletal Proteins (日) (読)
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| 7. | (英) Endocytosis (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Intracellular Space (日) (読)
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| 10. | (英) Membrane Proteins (日) (読)
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| 11. | (英) Models, Biological (日) (読)
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| 12. | (英) Protein Binding (日) (読)
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| 13. | (英) Protein Structure, Tertiary (日) (読)
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| 14. | (英) Protein Transport (日) (読)
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| 15. | (英) Tight Junctions (日) (読)
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| 16. | (英) rab GTP-Binding Proteins (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Molecular Biology of the Cell (The American Society for Cell Biology)
(pISSN: 1059-1524, eISSN: 1939-4586)
| ○ISSN (任意): | □ | 1939-4586
ISSN: 1059-1524
(pISSN: 1059-1524, eISSN: 1939-4586) Title: Molecular biology of the cellTitle(ISO): Mol Biol CellPublisher: American Society for Cell Biology (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 19
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 971 983
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 3月 初日 (平成 20年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1091/mbc.E07-06-0551 (→Scopusで検索)
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| ○PMID (任意): | □ | 18094055 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC2262956 (日)
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