『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=189897)

EID=189897EID:189897, Map:0, LastModified:2012年10月12日(金) 10:47:10, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[佐々木 卓也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kanda I. (日) (読)
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2.西村 範行
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3. (英) Nakatsuji H. (日) (読)
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4. (英) Yamamura R. (日) (読)
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5.中西 秀樹
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6.佐々木 卓也 ([徳島大学])
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題名 (必須): (英) Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Epithelial cell scattering recapitulates the first steps of carcinoma invasion/metastasis. While the balance between cell-cell adhesive activity and cell motility ultimately determines this process, its molecular mechanisms remain unclear. Adherence junctions and tight junctions (TJs) are primarily responsible for cell-cell adhesive activity and subjected to dynamic remodeling. We previously showed that Rab13 and its effector protein JRAB/MICAL-L2 mediate the endocytic recycling of the integral TJ protein occludin and the assembly of functional TJs. In this study, we examined the role of Rab13 and JRAB/MICAL-L2 in the scattering of Madin-Darby canine kidney (MDCK) cells in response to 12-O-tetradecanoylphorbol-13-acetate (TPA). Knockdown of Rab13 in canine MDCK cells suppressed the TPA-induced scattering, and this phenotype was restored by re-expression of human Rab13. During TPA-induced MDCK cell scattering, Rab13 was transiently activated and returned to its basal level, and both Rab13 and JRAB/MICAL-L2 were colocalized with F-actin at cell-cell contact sites and then accumulated at emerging lamellipodial structures. TPA-induced MDCK cell scattering was also inhibited by knockdown of canine JRAB/MICAL-L2 and rescued by re-expression of mouse JRAB/MICAL-L2. These results indicate that Rab13 and JRAB/MICAL-L2 are involved in epithelial cell scattering.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Carcinogens (日) (読) [継承]
3. (英) Cell Adhesion (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Cell Movement (日) (読) [継承]
6. (英) Cricetinae (日) (読) [継承]
7. (英) Cytoskeletal Proteins (日) (読) [継承]
8. (英) Dogs (日) (読) [継承]
9. (英) Epithelial Cells (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Microfilament Proteins (日) (読) [継承]
12. (英) Tetradecanoylphorbol Acetate (日) (読) [継承]
13. (英) rab GTP-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oncogene ([Nature Publishing Group])
(pISSN: 0950-9232, eISSN: 1476-5594)

ISSN (任意): 1476-5594
ISSN: 0950-9232 (pISSN: 0950-9232, eISSN: 1476-5594)
Title: Oncogene
Title(ISO): Oncogene
Publisher: Springer Science+Business Media
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 27 [継承]
(必須): 12 [継承]
(必須): 1687 1695 [継承]
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年月日 (必須): 西暦 2008年 3月 13日 (平成 20年 3月 13日) [継承]
URL (任意):
DOI (任意): 10.1038/sj.onc.1210812    (→Scopusで検索) [継承]
PMID (任意): 17891173    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● I. Kanda, Noriyuki Nishimura, H. Nakatsuji, R. Yamamura, Hideki Nakanishi and Takuya Sasaki : Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering., Oncogene, Vol.27, No.12, 1687-1695, 2008.
欧文冊子 ● I. Kanda, Noriyuki Nishimura, H. Nakatsuji, R. Yamamura, Hideki Nakanishi and Takuya Sasaki : Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering., Oncogene, Vol.27, No.12, 1687-1695, 2008.

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