『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=189852)

EID=189852EID:189852, Map:0, LastModified:2013年5月19日(日) 19:01:48, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐藤 陽一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sakamoto Kozue (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.新家 利一
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.勢井 雅子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.野村 以徂子
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.梅野 真由美
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.エヴィス アシュラフ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.中堀 豊
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Proteasome subunits mRNA expressions correlate with male BMI; implications for a role in obesity  (日)    [継承]
副題 (任意):
要約 (任意): (英) Obesity as well as its associated chronic diseases and adverse health consequences such as type 2 diabetes mellitus, dyslipidemia, hypertension, and coronary artery disease are afflicting middle-aged adults and an ever greater number of children globally. We planned to investigate new obesity-related factors using proteomics approaches in a randomly selected three high and three low BMI samples of Epstein-Barr-transformed B (EBV-B) lymphoblastoid cell lines prepared from two groups of young Japanese men with different BMI. To search novel obesity-related factors, comparisons of protein expressions between high and low BMI groups were carried out by two-dimensional gel electrophoresis (2-DE). Gene transcripts of proteasome subunits found out from 2-DE were further determined by quantitative real-time PCR. Results from proteomics approach showed that the expression of proteasome alpha subunit type 5 (PSMA5) was significantly lower in the high BMI male group than in those with low BMI (P < 0.05). To validate these results, we expanded the study to include 20 more men and used real-time PCR to quantify the mRNA expression level in their EBV-B cells. Both PSMA5 and PSMA2 of EBV-B cells showed negative correlation with BMI. Furthermore, the mRNA levels measured in the peripheral blood B lymphocytes for many proteasome subunits in 75 healthy men and women showed significant negative correlation with BMI in healthy men. Our findings suggest that proteasome expression may play a key role in obesity.  (日)    [継承]
キーワード (推奨): 1. (英) Body Mass Index (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) DNA Primers (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Herpesvirus 4, Human (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Obesity (日) (読) [継承]
9. (英) Polymerase Chain Reaction (日) (読) [継承]
10. (英) Proteasome Endopeptidase Complex (日) (読) [継承]
11. (英) Protein Subunits (日) (読) [継承]
12. (英) RNA, Messenger (日) (読) [継承]
13. (英) Reference Values (日) (読) [継承]
14. (英) Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Obesity (The Obesity Society)
(pISSN: 1930-7381, eISSN: 1930-739X)

ISSN (任意): 1930-7381
ISSN: 1930-7381 (pISSN: 1930-7381, eISSN: 1930-739X)
Title: Obesity (Silver Spring, Md.)
Title(ISO): Obesity (Silver Spring)
Supplier: The Obesity Society
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 17 [継承]
(必須): 5 [継承]
(必須): 1044 1049 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 4月 24日 (平成 21年 4月 24日) [継承]
URL (任意):
DOI (任意): 10.1038/oby.2008.612    (→Scopusで検索) [継承]
PMID (任意): 19165168    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Human Genetics and Public Health, Faculty of Medicine, Graduate School of Proteomics, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kozue Sakamoto, Youichi Sato, Toshikatsu Shinka, Masako Sei, Isoko Nomura, Mayumi Umeno, ASHRAF ABDEL AZIM EWIS and Yutaka Nakahori : Proteasome subunits mRNA expressions correlate with male BMI; implications for a role in obesity, Obesity, Vol.17, No.5, 1044-1049, 2009.
欧文冊子 ● Kozue Sakamoto, Youichi Sato, Toshikatsu Shinka, Masako Sei, Isoko Nomura, Mayumi Umeno, ASHRAF ABDEL AZIM EWIS and Yutaka Nakahori : Proteasome subunits mRNA expressions correlate with male BMI; implications for a role in obesity, Obesity, Vol.17, No.5, 1044-1049, 2009.

関連情報

Number of session users = 0, LA = 1.81, Max(EID) = 372521, Max(EOID) = 996304.