『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=189233EID:189233, Map:0, LastModified:2017年2月23日(木) 10:38:32, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[篠原 千尋], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.篠原 千尋
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2.山下 菊治
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3.松尾 敬志
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4.北村 清一郎
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5.河野 文昭 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.総合診療歯科学]/[徳島大学.病院.中央診療施設等.総合歯科診療部])
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題名 (必須): (英) Effects of Carbonic AnhydraseInhibitor Acetazolamide(AZ)on Osteoclasts and Bone Structure  (日)    [継承]
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要約 (任意): (英) We examined the changes of osteoclasts and bone structure in vivo and in vitro under the condition of low activity of bone resorption induced by acetazolamide (AZ). AZ is a specific inhibitor of carbonic anhydrase II (CA II), which is the enzyme indispensable for substantial proton generation by osteoclasts. In vivo study, we investigated histologically and histomorphometrically the changes of trabecular bone and osteoclasts at the cartilage-bone junction of tibiae in rats injected subcutaneously with AZ for 21 days. The area of trabecular bone of AZ treated group increased compared with control group. Moreover, AZ treatment decreased about 20% the number of osteoclasts at the cartilage-bone junction. In vitro study, we examined the effects of AZ on osteoclasts using culture system of rat bone marrow. The number of osteoclasts on the bone slice was suppressed by AZ of a concentration from 10^<-5> to 10^<-4> M in a doze-dependent manner. The number of osteoclasts cultured with 10^<-4>M AZ for 24 hours and with or without parathyroid hormone (PTH) on the bone slice and on the glass showed a significant decrease compared with the control group. Some osteoclasts treated with AZ showed morphological changes of apoptosis-like cell death, including shrinking of cytoplasm and fragmentation of nuclei. These results show that high-doze of AZ decreases bone resorption not only by inhibiting CA II but also by decreasing the number of osteoclasts via induction of cell death. This suggests that CA II plays an important role not only in proton formation but also in osteoclast survival.  (日)    [継承]
キーワード (推奨): 1. (英) Acetazolamide (日) (読) [継承]
2. (英) Bone (日) (読) [継承]
3. (英) Carbonic anhydrase II (日) (読) [継承]
4. (英) Osteoclast (日) (読) [継承]
発行所 (推奨): (英) The Society of Hard Tissue Biology (日) 硬組織再生生物学会 (読) [継承]
誌名 (必須): Journal of Hard Tissue Biology ([硬組織再生生物学会])
(pISSN: 1341-7649, eISSN: 1880-828X)

ISSN (任意): 1341-7649
ISSN: 1341-7649 (pISSN: 1341-7649, eISSN: 1880-828X)
Title: Journal of hard tissue biology
Title(ISO): J Hard Tissue Biol
Supplier: 硬組織再生生物学会
Publisher: Japanese Society of Hard Tissue Research & Technology
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 115 123 [継承]
都市 (任意): 東京 (Tokyo/[日本国]) [継承]
年月日 (必須): 西暦 2007年 10月 1日 (平成 19年 10月 1日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/110006570612/ [継承]
DOI (任意): 10.2485/jhtb.16.115    (→Scopusで検索) [継承]
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NAID (任意): 110006570612 [継承]
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和文冊子 ● Chihiro Shinohara, Kikuji Yamashita, Takashi Matsuo, Seiichiro Kitamura and Fumiaki Kawano : Effects of Carbonic AnhydraseInhibitor Acetazolamide(AZ)on Osteoclasts and Bone Structure, Journal of Hard Tissue Biology, Vol.16, No.3, 115-123, 2007.
欧文冊子 ● Chihiro Shinohara, Kikuji Yamashita, Takashi Matsuo, Seiichiro Kitamura and Fumiaki Kawano : Effects of Carbonic AnhydraseInhibitor Acetazolamide(AZ)on Osteoclasts and Bone Structure, Journal of Hard Tissue Biology, Vol.16, No.3, 115-123, 2007.

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