『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Takeda Koichi (日) (読)
役割 (任意): (英)   (日) 記述,考察   [継承]
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2. (英) Okuno Hiroko (日) (読)
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3. (英) Hata Takashi (日) (読)
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4. (英) Nishimoto Makoto (日) (読)
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5.松木 均 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意): (英)   (日) 考察   [継承]
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6.金品 昌志
役割 (任意): (英)   (日) 計画,解析,論文執筆の指導   [継承]
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学籍番号 (推奨):
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題名 (必須): (英) Interdigitation and vesicle-to-micelle transformation induced by a local anesthetic tetracaine in phospholipids bilayers  (日)    [継承]
副題 (任意):
要約 (任意): (英) The phase transitions of distearoyl- (DSPC), dipalmitoyl- (DPPC) and dimyristoyl-phosphatidylcholine (DMPC) bilayer membranes were observed by means of differential scanning calorimetry as a function of the concentration of a local anesthetic tetracaine hydrochloride (TC.HCl). The depression of both temperatures of the main- and pre-transition, which is accompanied by a decrease in enthalpy changes for both transitions, was observed initially by the addition of TC.HCl. Bilayer interdigitation, which is accompanied by an increase in enthalpy change for the main transition from the interdigitated gel phase to the liquid crystalline phase, was followed by disappearance of the pretransition. The TC.HCl concentration necessary for the bilayer interdigitation was found to be 10, 21 and 6 mmol kg(-1) for DSPC, DPPC and DMPC bilayers, respectively, which was not consistent with the order of acyl-chain length of lipids. Biphasic interactions for the interdigitation, that is, repulsive interaction between polar head groups and van der Waals attractive interaction between hydrophobic chains of lipids, were discussed. On the other hand, vesicle-to-micelle transformation, which is accompanied by a cooperative decrease in enthalpy change for the main transition, was observed at higher concentration of TC.HCl and was confirmed by the vesicle size determined by the dynamic light scattering. The longer the acyl-chain length of lipids, the higher the TC.HCl concentration necessary for the vesicle-to-micelle transformation.  (日)    [継承]
キーワード (推奨): 1. (英) Anesthetics, Local (日) (読) [継承]
2. (英) Calorimetry, Differential Scanning (日) (読) [継承]
3. (英) Dimyristoylphosphatidylcholine (日) (読) [継承]
4. (英) Lipid Bilayers (日) (読) [継承]
5. (英) Micelles (日) (読) [継承]
6. (英) Phase Transition (日) (読) [継承]
7. (英) Phospholipids (日) (読) [継承]
8. (英) Temperature (日) (読) [継承]
9. (英) Tetracaine (日) (読) [継承]
10. (英) Unilamellar Liposomes (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Colloids and Surfaces B:Biointerfaces ([Elsevier])
(pISSN: 0927-7765, eISSN: 1873-4367)

ISSN (任意): 1873-4367
ISSN: 0927-7765 (pISSN: 0927-7765, eISSN: 1873-4367)
Title: Colloids and surfaces. B, Biointerfaces
Title(ISO): Colloids Surf B Biointerfaces
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2009年 8月 初日 (平成 21年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.colsurfb.2009.03.026    (→Scopusで検索) [継承]
PMID (任意): 19403276    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Koichi Takeda, Hiroko Okuno, Takashi Hata, Makoto Nishimoto, Hitoshi Matsuki and Shoji Kaneshina : Interdigitation and vesicle-to-micelle transformation induced by a local anesthetic tetracaine in phospholipids bilayers, Colloids and Surfaces B:Biointerfaces, Vol.72, No.1, 135-140, 2009.
欧文冊子 ● Koichi Takeda, Hiroko Okuno, Takashi Hata, Makoto Nishimoto, Hitoshi Matsuki and Shoji Kaneshina : Interdigitation and vesicle-to-micelle transformation induced by a local anesthetic tetracaine in phospholipids bilayers, Colloids and Surfaces B:Biointerfaces, Vol.72, No.1, 135-140, 2009.

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