『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=188310EID:188310, Map:0, LastModified:2012年8月31日(金) 16:52:19, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.生命情報工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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2. (英) Koyama Daisuke (日) (読)
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3. (英) Otsuki Mamoru (日) (読)
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[継承]
4. (英) Otomo Naoki (日) (読)
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[継承]
5. (英) Shirai Tadashi (日) (読)
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[継承]
6. (英) Abe Chiaki (日) (読)
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[継承]
7.中田 栄司
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8.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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9.堀 均
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[継承]
題名 (必須): (英) A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics"  (日)    [継承]
副題 (任意):
要約 (任意): (英) Phytyl quinols, namely acyclic tocopherols, are key intermediates of tocopherol biosynthesis, but their biological activities remain unclear. We therefore investigated the structure-activity relationship of phytyl quinols to apply a chemical biosynthesis design for an antiatherosclerosis drug based on isoprenomics. We have achieved the biosynthesis-oriented design and synthesis of alpha- (TX-2254) and beta-(TX-2247) phytyl quinol as an unnatural intermediate, other gamma- (TX-2242) and delta-(TX-2231) phytyl quinol as a natural one. Geometry optimization and Molecular orbital (MO) calculation of TX-2254 showed a unique right-angle structure; however, MO energy of TX-2254 and d-alpha-tocopherol were very similar. Radical reactivity of TX-2231 was equal to dl-alpha-tocopherol, whereas TX-2254, TX-2247, and TX-2231 showed lower reactivity than dl-alpha-tocopherol. All four phytyl quinols showed almost the same moderate inhibitory activity against low-density lipoprotein (LDL) oxidation instead of their different degree of C-methylation with character different from tocopherols. In vivo toxicities of phytyl quinols against chick embryo chorioallantoic membrane (CAM) vasculature were hardly observed. We proposed phytyl quinols were possible antioxidants in plants and animals, like vitamin E.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antioxidants (日) (読) [継承]
3.動脈硬化 (atherosclerosis) [継承]
4. (英) Chemistry Techniques, Analytical (日) (読) [継承]
5. (英) Chick Embryo (日) (読) [継承]
6. (英) Drug Design (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Isomerism (日) (読) [継承]
9. (英) Models, Molecular (日) (読) [継承]
10.分子構造 (molecular structure) [継承]
11. (英) Tocopherols (日) (読) [継承]
発行所 (推奨): (英) Kluwer Academic/Plenum Publishers (日) (読) [継承]
誌名 (必須): Advances in Experimental Medicine and Biology ([Kluwer Academic Publishers])
(pISSN: 0065-2598)

ISSN (任意): 0065-2598
ISSN: 0065-2598 (pISSN: 0065-2598, eISSN: 2214-8019)
Title: Advances in experimental medicine and biology
Title(ISO): Adv. Exp. Med. Biol.
Publisher: Springer, Dordrecht.
 (NLM Catalog  (Scopus (Scopus information is found. [need login])
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(必須): 645 [継承]
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年月日 (必須): 西暦 2009年 3月 初日 (平成 21年 3月 初日) [継承]
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DOI (任意): 10.1007/978-0-387-85998-9_17    (→Scopusで検索) [継承]
PMID (任意): 19227458    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Minamijosanjimacho-2, Tokushima, 770-8506 Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoshihiro Uto, Daisuke Koyama, Mamoru Otsuki, Naoki Otomo, Tadashi Shirai, Chiaki Abe, Eiji Nakata, Hideko Nagasawa and Hitoshi Hori : A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics", Advances in Experimental Medicine and Biology, Vol.645, 109-114, 2009.
欧文冊子 ● Yoshihiro Uto, Daisuke Koyama, Mamoru Otsuki, Naoki Otomo, Tadashi Shirai, Chiaki Abe, Eiji Nakata, Hideko Nagasawa and Hitoshi Hori : A chemical biosynthesis design for an antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on "isoprenomics", Advances in Experimental Medicine and Biology, Vol.645, 109-114, 2009.

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