『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=188309)

EID=188309EID:188309, Map:0, LastModified:2012年10月3日(水) 16:05:05, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部 (2004年4月1日〜2015年3月31日/->組織[徳島大学.大学院医歯薬学研究部]) [継承]
著者 (必須): 1. (英) Miyake Kotaro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.西岡 将規 (->個人[發知 将規])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Sugimoto Koji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Batmunkh Erdenebulgan (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.堀 均
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer  (日)    [継承]
副題 (任意):
要約 (任意): (英) Purpose It is well known that hypoxic milieu is the primary cancer environment. Therefore, tumor hypoxia is considered to be a potential therapeutic target. In the present study, we investigated the antitumor and antimetastatic effect of hypoxic cell radiosensitizer, TX-1877 on xenograft model of rectal cancer. Methods Nude mice bearing subcutaneously or orthotopically implanted human colon cancer cell lines HCT-116 and HT-29 were treated with TX-1877, irradiation or TX-1877 with irradiation. Tumor volume, survival, expression of matrix metalloproteinase (MMP)-2, MMP-7, MMP-9 and urokinase-type plasminogen activator (uPA) and incidence of lymph node metastasis were evaluated in treatment versus control group. Results In subcutaneous model, tumor treated with TX-1877 and irradiation showed significant reductions in volume (P < 0.05 vs. control, TX-1877 or irradiation group). Quantitative real-time reverse transcription-PCR and immunohistochemical analysis revealed that TX-1877 significantly inhibited expression of the MMP-9 and uPA. These treatments also inhibited the para-aortic lymph node metastasis, however, did not prolong the survival in orthotopic model. Conclusions These data show that the treatment of TX-1877 with irradiation decreased growth of human rectal cancer and, furthermore, suppressed lymph node metastasis.  (日)    [継承]
キーワード (推奨): 1. (英) TX-1877 (日) (読) [継承]
2. (英) Radiosensitizer (日) (読) [継承]
3. (英) Hypoxic cell (日) (読) [継承]
4. (英) Antimetastasis (日) (読) [継承]
5. (英) Lymph node metastasis (日) (読) [継承]
発行所 (推奨): (英) Springer Berlin / Heidelberg (日) (読) [継承]
誌名 (必須): Cancer Chemotherapy and Pharmacology ([Springer-Verlag])
(pISSN: 0344-5704, eISSN: 1432-0843)

ISSN (任意): 1432-0843
ISSN: 0344-5704 (pISSN: 0344-5704, eISSN: 1432-0843)
Title: Cancer chemotherapy and pharmacology
Title(ISO): Cancer Chemother. Pharmacol.
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 64 [継承]
(必須): 5 [継承]
(必須): 885 892 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 10月 末日 (平成 21年 10月 末日) [継承]
URL (任意):
DOI (任意): 10.1007/s00280-009-0937-5    (→Scopusで検索) [継承]
PMID (任意): 19214512    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. kota166@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kotaro Miyake, Mitsuo Shimada, Masanori Nishioka, Koji Sugimoto, Erdenebulgan Batmunkh, Yoshihiro Uto, Hideko Nagasawa and Hitoshi Hori : Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer, Cancer Chemotherapy and Pharmacology, Vol.64, No.5, 885-892, 2009.
欧文冊子 ● Kotaro Miyake, Mitsuo Shimada, Masanori Nishioka, Koji Sugimoto, Erdenebulgan Batmunkh, Yoshihiro Uto, Hideko Nagasawa and Hitoshi Hori : Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer, Cancer Chemotherapy and Pharmacology, Vol.64, No.5, 885-892, 2009.

関連情報

Number of session users = 0, LA = 0.95, Max(EID) = 361546, Max(EOID) = 967713.