『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=187929EID:187929, Map:0, LastModified:2012年9月27日(木) 17:56:28, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[辻 明彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ソシオテクノサイエンス研究部.ライフシステム部門.生命情報工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1. (英) Yanagino Takuya (日) (読)
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2.湯浅 恵造 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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3.長浜 正巳
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4.松田 佳子
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5.辻 明彦
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題名 (必須): (英) Transcriptional Regulation of Fibrillin-2 Gene by E2F Family Members in Chondrocyte Differentiation  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mutation in fibrillin-2, a major structural component of extracellular microfibrils in connective tissue, results in the autosomal dominant disease congenital contractural arachnodactyly. This genetic disease is characterized by dolichostenomelia and arachnodactyly, in addition to contractures of the large joints and abnormal pinnae formation, thus indicating the significance of fibrillin-2 in chondrogenesis. In this study, we investigated the transcriptional regulation of fibrillin-2 in chondrogenic differentiation. Although mRNA expression of fibrillin-1, a highly homologous protein to fibrillin-2, remained almost unchanged during chondrogenesis of mouse ATDC5 cells, fibrillin-2 mRNA expression varied. Fibrillin-2 was highly expressed at the early stage and declined progressively during differentiation. The 5'-flanking region of the fibrillin-2 gene contains potential binding sites for E2F, Runx, AP-2, and Sox transcription factors. The promoter activity of fibrillin-2 decreased markedly following deletion and mutagenesis of the E2F binding site between -143 and -136 bp. Overexpression of E2F1 resulted in a marked increase in its promoter activity, whereas expression of other transcription factors including AP-2alpha and Runx2 had no effect. The increase in promoter activity by E2F1 was completely suppressed by the coexpression of E2F4. E2F2 and E2F3 had positive effects on the promoter activity. Although ATDC5 cells expressed transcripts for the E2F family genes at all stages of differentiation, the expression profiles differed. E2F1 expression remained almost unchanged, whereas E2F4 expression increased markedly at the late stage of differentiation. These results indicated that coordinated expression of the E2F family is critical for the transcriptional regulation of fibrillin-2 during chondrogenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Differentiation (日) (読) [継承]
3. (英) Cell Line (日) (読) [継承]
4. (英) Chondrocytes (日) (読) [継承]
5. (英) Chondrogenesis (日) (読) [継承]
6. (英) E2F Transcription Factors (日) (読) [継承]
7. (英) E2F1 Transcription Factor (日) (読) [継承]
8. (英) E2F2 Transcription Factor (日) (読) [継承]
9. (英) E2F3 Transcription Factor (日) (読) [継承]
10. (英) E2F4 Transcription Factor (日) (読) [継承]
11. (英) Gene Expression Regulation (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Microfilament Proteins (日) (読) [継承]
14. (英) RNA, Messenger (日) (読) [継承]
15. (英) Transcription, Genetic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cellular Biochemistry ([Wiley-Liss, Inc.])
(pISSN: 0730-2312, eISSN: 1097-4644)

ISSN (任意): 1097-4644
ISSN: 0730-2312 (pISSN: 0730-2312, eISSN: 1097-4644)
Title: Journal of cellular biochemistry
Title(ISO): J Cell Biochem
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2009年 3月 1日 (平成 21年 3月 1日) [継承]
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DOI (任意): 10.1002/jcb.22029    (→Scopusで検索) [継承]
PMID (任意): 19142862    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biological Science and Technology, the University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takuya Yanagino, Keizo Yuasa, Masami Nagahama, Yoshiko Matsuda and Akihiko Tsuji : Transcriptional Regulation of Fibrillin-2 Gene by E2F Family Members in Chondrocyte Differentiation, Journal of Cellular Biochemistry, Vol.106, No.4, 580-588, 2009.
欧文冊子 ● Takuya Yanagino, Keizo Yuasa, Masami Nagahama, Yoshiko Matsuda and Akihiko Tsuji : Transcriptional Regulation of Fibrillin-2 Gene by E2F Family Members in Chondrocyte Differentiation, Journal of Cellular Biochemistry, Vol.106, No.4, 580-588, 2009.

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