『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=187779EID:187779, Map:0, LastModified:2017年4月20日(木) 21:08:28, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[岡崎 拓], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sato Noriko (日) (読)
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2. (英) Ogawa Yoshihiro (日) (読)
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3. (英) Katsuura Goro (日) (読)
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4. (英) Tsuji Tetsuo (日) (読)
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5. (英) Masuzaki Hiroaki (日) (読)
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6. (英) Hiraoka Junko (日) (読)
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7.岡崎 拓
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8. (英) Tamaki Mikio (日) (読)
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9. (英) Hayase Minoru (日) (読)
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10. (英) Yoshimasa Yasunao (日) (読)
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11. (英) Nishi Shigeo (日) (読)
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12. (英) Hosoda Kiminori (日) (読)
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13. (英) Nakao Kazuwa (日) (読)
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題名 (必須): (英) Pathophysiological Significance of the Obese Gene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats.  (日)    [継承]
副題 (任意):
要約 (任意): (英) To explore the pathophysiological significance of the obese (ob) gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats, we examined the synthesis and secretion of leptin and its satiety effect in VMH-lesioned rats compared with those in sham-operated rats. Northern blot analysis revealed that ob gene expression is markedly augmented in the mesenteric and sc white adipose tissue, but remained unchanged in the epididymal white adipose tissue during the development of obesity in VMH-lesioned rats. Plasma leptin levels were relatively constant in sham-operated rats, but were elevated during the development of obesity in VMH-lesioned rats. In sham-operated rats, a single i.v. (1.0 mg/rat) or intracerebroventricular (2.0 micrograms/rat) injection of recombinant human leptin reduced food intake and body weight gain in sham-operated rats. By contrast, no significant effect on food intake or body weight gain was observed in VMH-lesioned rats. The present study provides evidence that VMH-lesioned rats overproduce leptin and increase its release but cannot respond to it and suggests that the loss of its satiety effect contributes to the development of obesity and the obesity-related phenotypes in VMH-lesioned rats.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Humans (日) (読) [継承]
3. (英) Hypothalamus, Middle (日) (読) [継承]
4. (英) Injections, Intravenous (日) (読) [継承]
5. (英) Injections, Intraventricular (日) (読) [継承]
6. (英) Leptin (日) (読) [継承]
7. (英) Proteins (日) (読) [継承]
8. (英) Radioimmunoassay (日) (読) [継承]
9. (英) Rats (日) (読) [継承]
10. (英) Rats, Sprague-Dawley (日) (読) [継承]
11. (英) Recombinant Proteins (日) (読) [継承]
12. (英) Satiety Response (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 138 [継承]
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(必須): 947 954 [継承]
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年月日 (必須): 西暦 1997年 3月 初日 (平成 9年 3月 初日) [継承]
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DOI (任意): 10.1210/endo.138.3.4989    (→Scopusで検索) [継承]
PMID (任意): 9048594    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Noriko Sato, Yoshihiro Ogawa, Goro Katsuura, Tetsuo Tsuji, Hiroaki Masuzaki, Junko Hiraoka, Taku Okazaki, Mikio Tamaki, Minoru Hayase, Yasunao Yoshimasa, Shigeo Nishi, Kiminori Hosoda and Kazuwa Nakao : Pathophysiological Significance of the Obese Gene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats., Endocrinology, Vol.138, No.3, 947-954, 1997.
欧文冊子 ● Noriko Sato, Yoshihiro Ogawa, Goro Katsuura, Tetsuo Tsuji, Hiroaki Masuzaki, Junko Hiraoka, Taku Okazaki, Mikio Tamaki, Minoru Hayase, Yasunao Yoshimasa, Shigeo Nishi, Kiminori Hosoda and Kazuwa Nakao : Pathophysiological Significance of the Obese Gene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats., Endocrinology, Vol.138, No.3, 947-954, 1997.

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