『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=187524EID:187524, Map:0, LastModified:2012年10月4日(木) 15:24:46, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[北岡 和義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.生理機能学 (2004年4月1日〜2015年3月31日) [継承]
2.統合生理学 (2004年4月1日〜2015年3月31日) [継承]
3.臨床食管理学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.北岡 和義 ([徳島大学.教養教育院])
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[継承]
2. (英) Uchida Kaoru (日) 内田 薫 (読)
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[継承]
3. (英) Okamoto Naoko (日) 岡本 直子 (読)
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4.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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5. (英) Miyazaki Toshitsugu (日) 宮崎 寿次 (読)
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[継承]
6.武田 英二
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[継承]
7.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Fermented ginseng improves the first-night effect in humans  (日)    [継承]
副題 (任意):
要約 (任意): (英) The goal of this study was to clarify whether ginseng fermented by lactic acid bacteria (fermented ginseng, FG), can improve the first-night effect (FNE) in humans. Behavioral tests and quantification of mRNA expression related to GABAergic neurotransmission in brain (glutamic acid decarboxylase 1, gamma-aminobutyrate aminotransferase [Abat], gamma-aminobutyric acid transporter 1 [GAT1], gamma-aminobutyric acid transporter 4, gamma-aminobutyric acid A receptor subunit alpha 1 and gamma-aminobutyric acid A receptor subunit alpha 2) were carried out in FG-treated mice. We also performed double-blind sleep recordings of human subjects given FG or placebo. A university-based sleep laboratory. Sixteen healthy male volunteers (aged 20.69 +/- 0.44 years) were observed in the human study. At the end of administration, 2 consecutive all-night polysomnography recordings were performed. Subjects also completed psychological questionnaires, and urine and saliva samples were taken to analyze stress-sensitive markers. The light-dark transition test demonstrated that FG had some anxiolytic effect in mice, but other anxiety measures were unaffected. The hippocampal mRNA expression showed a decrease of Abat and GAT1 suggesting an increase of GABA. Other regions (amygdala and cerebellum) showed no differences. Furthermore, there was some evidence (using simple pairwise comparisons but not supported in the full ANOVA model) that administration of FG tended to diminish decreases in total sleep time and sleep efficiency (seen as first night effects in the placebo group) without affecting sleep architecture. Our results suggest the administration of FG could improve the FNE in humans. The improvement may be related to an anxiolytic effect of FG which acts via GABAergic modification.  (日)    [継承]
キーワード (推奨): 1.睡眠 (sleep) [継承]
発行所 (推奨):
誌名 (必須): Sleep (Associated Professional Sleep Societies)
(pISSN: 0161-8105, eISSN: 1550-9109)

ISSN (任意): 0161-8105
ISSN: 0161-8105 (pISSN: 0161-8105, eISSN: 1550-9109)
Title: Sleep
Title(ISO): Sleep
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 32 [継承]
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(必須): 413 421 [継承]
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年月日 (必須): 西暦 2009年 3月 1日 (平成 21年 3月 1日) [継承]
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PMID (任意): 19294962    (→Scopusで検索) [継承]
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WOS (任意): 000263705500016 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Integrative Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) OtherID: PMC2647796  (日)    [継承]

標準的な表示

和文冊子 ● Kazuyoshi Kitaoka, Kaoru Uchida, Naoko Okamoto, Sachiko Chikahisa, Toshitsugu Miyazaki, Eiji Takeda and Hiroyoshi Sei : Fermented ginseng improves the first-night effect in humans, Sleep, Vol.32, No.3, 413-421, 2009.
欧文冊子 ● Kazuyoshi Kitaoka, Kaoru Uchida, Naoko Okamoto, Sachiko Chikahisa, Toshitsugu Miyazaki, Eiji Takeda and Hiroyoshi Sei : Fermented ginseng improves the first-night effect in humans, Sleep, Vol.32, No.3, 413-421, 2009.

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