『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=187439)

EID=187439EID:187439, Map:0, LastModified:2013年6月27日(木) 10:50:03, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nakamuta Shinichi (日) (読)
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2. (英) Endo Hiroshi (日) (読)
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[継承]
3. (英) Higashi Youichiro (日) (読)
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[継承]
4. (英) Kousaka Aoi (日) (読)
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[継承]
5. (英) Kousaka Aoi (日) (読)
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[継承]
6.矢野 仁康
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[継承]
7.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) HIV-1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) The infiltration of human immunodeficiency virus (HIV)-1, such as by HIV-infected leukocytes, across an injured blood-brain barrier (BBB) is a characteristic pathologic manifestation of HIV-1-associated dementia. HIV-1 gp120 has been implicated as a cause of breakdown of tight junctions between endothelial cells of the BBB, though the disrupting molecular mechanisms are unexplained. This study offers a new explanation for the increased BBB microvascular permeability, due to the degradation of tight junction proteins by the proteasome induced by gp120, and the negative regulation of this process by the scaffold protein, 14-3-3tau. gp120 reduced the amount of zonula occludens (ZO)-1 and ZO-2 in human brain microvascular endothelial cells (HBMECs). The treatment of HBMECs with the proteasome inhibitor, lactacystin, blocked the degradation of ZO-1 and ZO-2, suggesting that these proteins were targeted by gp120 for degradation by the proteasome. gp120 also specifically increased the expression of 14-3-3tau in HBMECs, and its down-regulation by RNAi facilitated the breakdown of tight junction proteins induced by gp120. Our results demonstrate the novel molecular mechanisms of the BBB breakdown by gp120.  (日)    [継承]
キーワード (推奨): 1. (英) 14-3-3 Proteins (日) (読) [継承]
2. (英) AIDS Dementia Complex (日) (読) [継承]
3.血液脳関門 (blood-brain barrier) [継承]
4. (brain) [継承]
5. (英) Capillary Permeability (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Endothelial Cells (日) (読) [継承]
8. (英) Endothelium, Vascular (日) (読) [継承]
9. (英) Gene Expression Regulation (日) (読) [継承]
10. (英) HIV Envelope Protein gp120 (日) (読) [継承]
11. (英) HIV-1 (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Membrane Proteins (日) (読) [継承]
14. (英) Phosphoproteins (日) (読) [継承]
15. (英) Proteasome Endopeptidase Complex (日) (読) [継承]
16. (英) Tight Junctions (日) (読) [継承]
17. (英) Transcriptional Activation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of NeuroVirology (International Society for NeuroVirology)
(pISSN: 1355-0284, eISSN: 1538-2443)

ISSN (任意): 1538-2443
ISSN: 1355-0284 (pISSN: 1355-0284, eISSN: 1538-2443)
Title: Journal of neurovirology
Title(ISO): J Neurovirol
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2008年 5月 初日 (平成 20年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1080/13550280801993630    (→Scopusで検索) [継承]
PMID (任意): 18569453    (→Scopusで検索) [継承]
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WOS (任意): 000256978400002 [継承]
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備考 (任意): 1.(英) Article.Affiliation: The Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shinichi Nakamuta, Hiroshi Endo, Youichiro Higashi, Aoi Kousaka, Aoi Kousaka, Mihiro Yano and Hiroshi Kido : HIV-1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells, Journal of NeuroVirology, Vol.14, No.3, 186-195, 2008.
欧文冊子 ● Shinichi Nakamuta, Hiroshi Endo, Youichiro Higashi, Aoi Kousaka, Aoi Kousaka, Mihiro Yano and Hiroshi Kido : HIV-1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells, Journal of NeuroVirology, Vol.14, No.3, 186-195, 2008.

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