『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=187424EID:187424, Map:0, LastModified:2012年8月28日(火) 15:41:20, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.矢野 仁康
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Shinichi Nakamuta (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Mayumi Shiota (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Hiroshi Endo (日) (読)
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学籍番号 (推奨):
[継承]
5.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Gatekeeper Role of 14-3-3τ Protein in HIV-1 gp120-Mediated Apotosis of Human Endothelial Cells by Inactivation of Bad  (日)    [継承]
副題 (任意):
要約 (任意): (英) HIV-1-associated dementia (HAD) is a major neurological complication often observed in the advanced stages of AIDS. We have reported that 14-3-3 proteins in cerebrospinal fluid, reflecting neuronal cell destruction, is a real-time marker of HAD progression. This study was designed to examine the role of 14-3-3 proteins in HAD. An in-vitro human umbilical vein endothelial cells (HUVEC) model of gp120 protein-induced apoptosis to study the protective role of 14-3-3 in HIV-1 gp120/CXCR4-mediated cell death. The alpha-chemokine receptor-mediated cell death by HIV-1 envelope protein, gp120, the critical event that causes neuron loss and endothelial cell injury, was evaluated in HUVEC undergoing gp120-induced apoptosis through the CXCR4 receptor. We studied the effects of siRNA for each 14-3-3 isoform on the death of HUVEC treated with CXCR4-preferring gp120 (IIIB). Gp120 increased the expression of 14-3-3tau in HUVEC. The binding of Gp120 to CXCR4 induced apoptosis of HUVEC through decreased binding of 14-3-3tau to the pro-apoptotic molecule, Bad. Treatment of the cells with dsRNA against 14-3-3tau enhanced the gp120-mediated dephosphorylation of Bad and its association with Bcl-XL in mitochondria, accelerating the gp120-induced apoptosis, whereas suppression of Bad by RNAi rescued the cells from apoptosis triggered by gp120. The specific up-regulation of 14-3-3tau in HUVEC negatively regulated gp120/CXCR4-mediated cell death by protecting Bad dephosphorylation.  (日)    [継承]
キーワード (推奨): 1. (英) 14-3-3 Proteins (日) (読) [継承]
2. (英) Apoptosis (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Cytochromes c (日) (読) [継承]
5. (英) Cytosol (日) (読) [継承]
6. (英) Down-Regulation (日) (読) [継承]
7. (英) Endothelium, Vascular (日) (読) [継承]
8. (英) HIV Envelope Protein gp120 (日) (読) [継承]
9. (英) HIV Envelope Protein gp160 (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Mitochondria (日) (読) [継承]
12. (英) Phosphorylation (日) (読) [継承]
13. (英) Recombinant Proteins (日) (読) [継承]
14. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
15. (英) Translocation, Genetic (日) (読) [継承]
16. (英) Up-Regulation (日) (読) [継承]
17. (英) bcl-Associated Death Protein (日) (読) [継承]
発行所 (推奨):
誌名 (必須): AIDS (International AIDS Society)
(pISSN: 0269-9370, eISSN: 1473-5571)

ISSN (任意): 0269-9370
ISSN: 0269-9370 (pISSN: 0269-9370, eISSN: 1473-5571)
Title: AIDS (London, England)
Title(ISO): AIDS
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 21 [継承]
(必須): 8 [継承]
(必須): 911 920 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 5月 11日 (平成 19年 5月 11日) [継承]
URL (任意):
DOI (任意): 10.1097/QAD.0b013e32810539f3    (→Scopusで検索) [継承]
PMID (任意): 17457084    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mihiro Yano, Nakamuta Shinichi, Shiota Mayumi, Endo Hiroshi and Hiroshi Kido : Gatekeeper Role of 14-3-3τ Protein in HIV-1 gp120-Mediated Apotosis of Human Endothelial Cells by Inactivation of Bad, AIDS, Vol.21, No.8, 911-920, 2007.
欧文冊子 ● Mihiro Yano, Nakamuta Shinichi, Shiota Mayumi, Endo Hiroshi and Hiroshi Kido : Gatekeeper Role of 14-3-3τ Protein in HIV-1 gp120-Mediated Apotosis of Human Endothelial Cells by Inactivation of Bad, AIDS, Vol.21, No.8, 911-920, 2007.

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