『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=187229EID:187229, Map:0, LastModified:2012年9月2日(日) 21:35:37, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉本 勝彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1.銭 志栄
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2. (英) Asa L Sylvia (日) (読)
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3.塩見 春彦
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4.塩見 美喜子
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5.吉本 勝彦
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6. (英) Yamada Shozo (日) (読)
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7. (英) Wang Lu Elaine (日) (読)
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8. (英) Rahman Mustafizur Md (日) (読)
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9.井上 寛
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10.板倉 光夫
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11.工藤 英治
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12.佐野 壽昭
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題名 (必須): (英) Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas.  (日)    [継承]
副題 (任意):
要約 (任意): (英) High-mobility group A2 is highly expressed during embryogenesis and in various benign and malignant tumors. Recent studies report that high-mobility group A2 is negatively regulated by the let-7 microRNAs (miRNAs) family in vitro. The development of pituitary adenomas in high-mobility group A2 transgenic mice showed that high-mobility group A2 may be involved in pituitary tumorigenesis. However, no studies have investigated the clinical significance of high-mobility group A2 and its relationship to the let-7 miRNA family in human pituitary adenomas. Using immunohistochemistry, we analyzed high-mobility group A2 expression with respect to various clinicopathologic factors in 98 pituitary adenomas. Overexpression of high-mobility group A2 was observed in 39% (38/98) of pituitary adenomas compared with normal adenohypophysial tissue and was frequently found in adenomas including prolactin (PRL), adrenocorticotrophic hormone, or follicle-stimulating hormone/luteinizing hormone and in null cell adenomas, but relatively rare in growth hormone (GH) and mixed GH/PRL adenomas. High-mobility group A2 expression was significantly associated with tumor invasion (P<0.05) and was significantly higher in grade IV than in grades I, II, and III adenomas (P<0.05). High levels of high-mobility group A2 expression were more frequently observed in macroadenomas than in microadenomas (P<0.05). High levels of high-mobility group A2 expression also significantly correlated with the proliferation marker Ki-67 (P<0.0001). Real-time quantitative RT-PCR analysis was carried out to evaluate the expression of let-7 in 55 pituitary adenomas. Subsequently, decreased expression of let-7 was confirmed in 23 of 55 (42%) adenomas and was correlated with high-grade tumors (P<0.05). An inverse correlation between let-7 and high-mobility group A2 expression was evident (R=-0.33, P<0.05). These findings support a causal link between let-7 and high-mobility group A2 whereby loss of let-7 expression induces high-mobility group A2 upregulation that represents an important mechanism in pituitary tumorigenesis and progression.  (日)    [継承]
キーワード (推奨): 1. (英) Adenoma (日) (読) [継承]
2. (英) Disease Progression (日) (読) [継承]
3. (英) Female (日) (読) [継承]
4. (英) Gene Expression (日) (読) [継承]
5. (英) HMGA2 Protein (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Immunohistochemistry (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) MicroRNAs (日) (読) [継承]
10. (英) Pituitary Neoplasms (日) (読) [継承]
11. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
12. (英) Tumor Markers, Biological (日) (読) [継承]
13. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Modern Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0893-3952, eISSN: 1530-0285)

ISSN (任意): 1530-0285
ISSN: 0893-3952 (pISSN: 0893-3952, eISSN: 1530-0285)
Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Title(ISO): Mod Pathol
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 431 441 [継承]
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年月日 (必須): 西暦 2009年 1月 9日 (平成 21年 1月 9日) [継承]
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DOI (任意): 10.1038/modpathol.2008.202    (→Scopusで検索) [継承]
PMID (任意): 19136928    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School of Medicine, Tokushima, Japan. zrqian@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Zhi-Rong Qian, Sylvia L Asa, Haruhiko Siomi, Mikiko Siomi, Katsuhiko Yoshimoto, Shozo Yamada, Elaine Lu Wang, Md Mustafizur Rahman, Hiroshi Inoue, Mitsuo Itakura, Eiji Kudo and Toshiaki Sano : Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas., Modern Pathology, Vol.22, No.3, 431-441, 2009.
欧文冊子 ● Zhi-Rong Qian, Sylvia L Asa, Haruhiko Siomi, Mikiko Siomi, Katsuhiko Yoshimoto, Shozo Yamada, Elaine Lu Wang, Md Mustafizur Rahman, Hiroshi Inoue, Mitsuo Itakura, Eiji Kudo and Toshiaki Sano : Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas., Modern Pathology, Vol.22, No.3, 431-441, 2009.

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