『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=187227)

EID=187227EID:187227, Map:0, LastModified:2012年8月28日(火) 19:53:03, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[沼田 周助], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患プロテオゲノム研究センター (2008年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.プロテオゲノム研究領域]) [継承]
著者 (必須): 1. (英) Kunika Kiyoshi (日) (読)
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[継承]
2.棚橋 俊仁
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[継承]
3.沼田 周助 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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[継承]
4.上野 修一
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学籍番号 (推奨):
[継承]
5.大森 哲郎
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学籍番号 (推奨):
[継承]
6. (英) Nakamura Naoto (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Tsugawa Kazue (日) (読)
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学籍番号 (推奨):
[継承]
8.宮脇 克行 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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[継承]
9.森谷 眞紀 (香川小児病院)
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[継承]
10.井上 寛
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11.板倉 光夫
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[継承]
題名 (必須): (英) Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects  (日)    [継承]
副題 (任意):
要約 (任意): (英) Genetic variants of the transcription factor 7-like 2 (TCF7L2) gene affect the risk of type 2 diabetes in populations with multiple ethnic groups. However, a comprehensive survey of this gene has not been done for a Japanese population. Thus, we conducted this gene-based association study, in which the common genetic variants were analyzed. Using 24 Japanese type 2 diabetic subjects, we first screened a 9.5 kb region, which included the entire coding sequence, to assess potential functional variants of TCF7L2. Sequencing revealed a common coding variant (Pro477Thr) in exon 14 of TCF7L2 that was not enrolled in the public SNP database. Nineteen SNPs and the microsatellite DG10S478 were genotyped across the gene in 2,877 unrelated Japanese subjects. This independent screen identified the previously reported rs7903146 with a strongest association (allele P = 0.0001, odds ratio = 1.59 [95% confidence interval 1.25-2.01]), but there was no significant association between Pro477Thr and type 2 diabetes (allele P = 0.64). Expression of the Pro477Thr variant did not alter TCF7L2 expression in 30 lymphoblast cells. Although a genotypic effect of Pro477Thr on expression of TCF7L2 was not apparent, Pro477Thr was identified as a common variant of TCF7L2 in 2,877 Japanese subjects. Further functional studies are required to determine the possible effect of this coding variant on type 2 diabetes.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Case-Control Studies (日) (読) [継承]
3. (英) Codon (日) (読) [継承]
4. (英) Diabetes Mellitus, Type 2 (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Genetic Predisposition to Disease (日) (読) [継承]
7. (英) Genotype (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.日本 (Japan) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Polymerase Chain Reaction (日) (読) [継承]
13. (英) Polymorphism, Single Nucleotide (日) (読) [継承]
14. (英) Risk Factors (日) (読) [継承]
15. (英) TCF Transcription Factors (日) (読) [継承]
16. (英) Transcription Factor 7-Like 2 Protein (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Human Genetics (日本人類遺伝学会)
(pISSN: 1434-5161, eISSN: 1435-232X)

ISSN (任意): 1434-5161
ISSN: 1434-5161 (pISSN: 1434-5161, eISSN: 1435-232X)
Title: Journal of human genetics
Title(ISO): J Hum Genet
Publisher: Springer Nature
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 53 [継承]
(必須): 11-12 [継承]
(必須): 972 982 [継承]
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年月日 (必須): 西暦 2008年 11月 18日 (平成 20年 11月 18日) [継承]
URL (任意):
DOI (任意): 10.1007/s10038-008-0339-2    (→Scopusで検索) [継承]
PMID (任意): 19012045    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Genetic Information, Institute for Genome Research, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kiyoshi Kunika, Toshihito Tanahashi, Shusuke Numata, Shu-ichi Ueno, Tetsuro Ohmori, Naoto Nakamura, Kazue Tsugawa, Katsuyuki Miyawaki, Maki Moritani, Hiroshi Inoue and Mitsuo Itakura : Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects, Journal of Human Genetics, Vol.53, No.11-12, 972-982, 2008.
欧文冊子 ● Kiyoshi Kunika, Toshihito Tanahashi, Shusuke Numata, Shu-ichi Ueno, Tetsuro Ohmori, Naoto Nakamura, Kazue Tsugawa, Katsuyuki Miyawaki, Maki Moritani, Hiroshi Inoue and Mitsuo Itakura : Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects, Journal of Human Genetics, Vol.53, No.11-12, 972-982, 2008.

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