『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=187113)

EID=187113EID:187113, Map:0, LastModified:2012年9月26日(水) 13:27:52, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宮脇 克行], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患プロテオゲノム研究センター (2008年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.プロテオゲノム研究領域]) [継承]
著者 (必須): 1.棚橋 俊仁
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2. (英) Shinohara Keiko (日) (読)
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3. (英) Keshavarz Parvaneh (日) (読)
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4. (英) Yamaguchi Yuka (日) (読)
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5.宮脇 克行 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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6. (英) Kunika Kiyoshi (日) (読)
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7.森谷 眞紀 (香川小児病院)
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8. (英) Nakamura Naoto (日) (読)
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9.吉川 敏一 ([京都府立医科大学])
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10.塩田 洋
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11.井上 寛
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12.板倉 光夫
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題名 (必須): (英) The association of genetic variants in Krüppel-like factor 11 and Type 2 diabetes in the Japanese population.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Krüppel-like factor 11 (KLF11) is a transcriptional factor of the zinc finger domain family that regulates the expression of insulin. In North European populations, its common functional variant Q62R (rs35927125) is a strong genetic factor for Type 2 diabetes (P = 0.00033, odds ratio for G allele = 1.29, 95% CI 1.12-1.49). We examined the contribution of KLF11 variants to the susceptibility to Type 2 diabetes in a Japanese population. By re-sequencing Japanese individuals (n = 24, partly 96), we screened all four exons, exon/intron boundaries and flanking regions of KLF11. Verified single nucleotide polymorphisms (SNPs) were genotyped in 731 initial samples (369 control and 362 case subjects). Subsequently, we tested for association in 1087 samples (524 control and 563 case subjects), which were collected in different districts of Japan from the initial samples. We identified eight variants, including a novel A/C variant on intron 3, but no mis-sense mutations. In an association study, we failed to find any significant result of SNPs (minor allele frequency 8.2-46.2%) after correcting for multiple testing. Similarly, no haplotypes were associated with Type 2 diabetes. It is notable that the G allele in rs35927125 was completely absent in 1818 Japanese individuals. Genetic variants in KLF11 are unlikely to have a major effect of Type 2 diabetes in the Japanese population, although they were significantly associated in North European populations. These observations might help to determine the role of KLF11 variants in Type 2 diabetes in different populations.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Analysis of Variance (日) (読) [継承]
3. (英) Asian Continental Ancestry Group (日) (読) [継承]
4. (英) Cell Cycle Proteins (日) (読) [継承]
5. (英) Diabetes Mellitus, Type 2 (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Gene Frequency (日) (読) [継承]
8. (英) Genetic Predisposition to Disease (日) (読) [継承]
9. (英) Genotype (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Insulin (日) (読) [継承]
12. (英) Japan (日) (読) [継承]
13. (英) Linkage Disequilibrium (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Middle Aged (日) (読) [継承]
16. (英) Repressor Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Diabetic Medicine (British Diabetic Association)
(pISSN: 0742-3071, eISSN: 1464-5491)

ISSN (任意): 1464-5491
ISSN: 0742-3071 (pISSN: 0742-3071, eISSN: 1464-5491)
Title: Diabetic medicine : a journal of the British Diabetic Association
Title(ISO): Diabet Med
Supplier: Diabetes UK
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 25 [継承]
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(必須): 19 26 [継承]
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年月日 (必須): 西暦 2008年 1月 初日 (平成 20年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1464-5491.2007.02315.x    (→Scopusで検索) [継承]
PMID (任意): 18199129    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Genetic Information, Institute for Genome Research, University of Tokushima, Tokushima, Japan. tana@genome.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC3228237  (日)    [継承]

標準的な表示

和文冊子 ● Toshihito Tanahashi, Keiko Shinohara, Parvaneh Keshavarz, Yuka Yamaguchi, Katsuyuki Miyawaki, Kiyoshi Kunika, Maki Moritani, Naoto Nakamura, Toshikazu Yoshikawa, Hiroshi Shiota, Hiroshi Inoue and Mitsuo Itakura : The association of genetic variants in Krüppel-like factor 11 and Type 2 diabetes in the Japanese population., Diabetic Medicine, Vol.25, No.1, 19-26, 2008.
欧文冊子 ● Toshihito Tanahashi, Keiko Shinohara, Parvaneh Keshavarz, Yuka Yamaguchi, Katsuyuki Miyawaki, Kiyoshi Kunika, Maki Moritani, Naoto Nakamura, Toshikazu Yoshikawa, Hiroshi Shiota, Hiroshi Inoue and Mitsuo Itakura : The association of genetic variants in Krüppel-like factor 11 and Type 2 diabetes in the Japanese population., Diabetic Medicine, Vol.25, No.1, 19-26, 2008.

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