『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=187104EID:187104, Map:0, LastModified:2018年6月27日(水) 16:49:16, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宮脇 克行], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.ゲノム機能研究センター (〜2008年3月31日/->組織[徳島大学.疾患プロテオゲノム研究センター]) [継承]
著者 (必須): 1.山下 裕紀子
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[継承]
2.井上 寛
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[継承]
3. (英) Parvaneh Keshavarz (日) (読)
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[継承]
4.宮脇 克行 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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[継承]
5. (英) Yamaguchi Yuka (日) (読)
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[継承]
6.森谷 眞紀 (香川小児病院)
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[継承]
7. (英) Kunika Kiyoshi (日) (読)
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[継承]
8. (英) Nakamura Naoto (日) (読)
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[継承]
9.吉川 敏一 ([京都府立医科大学])
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[継承]
10.安井 夏生
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[継承]
11.塩田 洋
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12.棚橋 俊仁
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13.板倉 光夫
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題名 (必須): (英) SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Many genetic association studies support a contribution of genetic variants in the KCNJ11-ABCC8 gene locus to type 2 diabetes (T2D) susceptibility in Caucasians. In non-Caucasian populations, however, there have been only a few association studies, and discordant results were obtained. Herein, we selected a total of 31 SNPs covering a 211.3-kb region of the KCNJ11-ABCC8 locus, characterized the patterns of linkage disequilibrium (LD) and haplotype structure, and performed a case-control association study in a Japanese population consisting of 909 T2D patients and 893 control subjects. We found significant associations between eight SNPs, including the KCNJ11 E23K and ABCC8 S1369A variants, and T2D. These disease-associated SNPs were genetically indistinguishable because of the presence of strong LD, as found previously in Caucasians. For the KCNJ11 E23K variant, the most significant association was obtained under a dominant genetic model (OR 1.32, 95% CI 1.09-1.60, P = 0.004). A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility. Furthermore, we found evidence suggesting that the KCNJ11 E23K genotype is independently associated with higher blood-pressure levels.  (日)    [継承]
キーワード (推奨): 1. (英) ATP-Binding Cassette Transporters (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Asian Continental Ancestry Group (日) (読) [継承]
4.血圧 (blood pressure) [継承]
5. (英) Diabetes Mellitus, Type 2 (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8.日本 (Japan) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Middle Aged (日) (読) [継承]
11. (英) Polymorphism, Single Nucleotide (日) (読) [継承]
12. (英) Potassium Channels (日) (読) [継承]
13. (英) Potassium Channels, Inwardly Rectifying (日) (読) [継承]
14. (英) Receptors, Drug (日) (読) [継承]
発行所 (推奨): Springer-Verlag.シュプリンガー ジャパン [継承]
誌名 (必須): Journal of Human Genetics (日本人類遺伝学会)
(pISSN: 1434-5161, eISSN: 1435-232X)

ISSN (任意): 1434-5161
ISSN: 1434-5161 (pISSN: 1434-5161, eISSN: 1435-232X)
Title: Journal of human genetics
Title(ISO): J Hum Genet
Publisher: Springer Nature
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 52 [継承]
(必須): 10 [継承]
(必須): 781 793 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 9月 6日 (平成 19年 9月 6日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/10019776159/ [継承]
DOI (任意): 10.1007/s10038-007-0190-x    (→Scopusで検索) [継承]
PMID (任意): 17823772    (→Scopusで検索) [継承]
NAID (任意): 10019776159 [継承]
WOS (任意): 000249919000001 [継承]
Scopus (任意): 2-s2.0-34848895423 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Genetic Information, Institute for Genome Research, The University of Tokushima, #3-18-15, Kuramoto-cho, Tokushima-city, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yukiko Yamashita, Hiroshi Inoue, Keshavarz Parvaneh, Katsuyuki Miyawaki, Yuka Yamaguchi, Maki Moritani, Kiyoshi Kunika, Naoto Nakamura, Toshikazu Yoshikawa, Natsuo Yasui, Hiroshi Shiota, Toshihito Tanahashi and Mitsuo Itakura : SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population., Journal of Human Genetics, Vol.52, No.10, 781-793, 2007.
欧文冊子 ● Yukiko Yamashita, Hiroshi Inoue, Keshavarz Parvaneh, Katsuyuki Miyawaki, Yuka Yamaguchi, Maki Moritani, Kiyoshi Kunika, Naoto Nakamura, Toshikazu Yoshikawa, Natsuo Yasui, Hiroshi Shiota, Toshihito Tanahashi and Mitsuo Itakura : SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population., Journal of Human Genetics, Vol.52, No.10, 781-793, 2007.

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