『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=187089EID:187089, Map:0, LastModified:2017年3月13日(月) 16:07:11, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[福井 清], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1.劉 莉 ([分子酵素学研究センター])
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2.坂井 隆志
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3.チャン ホアンナム ([徳島大学.高等教育研究センター.学修支援部門]/[徳島大学.国際センター])
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学籍番号 (推奨):
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4. (英) Mukai-Sakai Rika (日) 坂井 利佳 (読) さかい りか
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[継承]
5.梶 龍兒
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6.福井 清 ([徳島大学])
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[継承]
題名 (必須): (英) Nucling interacts with nuclear factor-B, regulating its cellular distribution  (日)    [継承]
副題 (任意):
要約 (任意): (英) Nucling is an Apaf1-binding proapoptotic protein involved in apoptosome-mediated apoptosis. Luciferase assays have revealed that the activation of nuclear factor-kappaB induced by tumor necrosis factor-alpha, interleukin-1beta and lipopolysaccharide is downregulated by the overexpression of Nucling in HEK293 cells. Moreover, the expression of endogenous cyclooxygenase 2, tumor necrosis factor-alpha and galectin-3, the end-point molecules in the pathway for the activation of nuclear factor-kappaB, as well as nuclear factor-kappaB (p65) itself, is upregulated in Nucling gene-deficient mouse embryonic fibroblasts, suggesting that nuclear factor-kappaB is a target of Nucling. Subsequent study has revealed that Nucling physically interacts with nuclear factor-kappaB (p65 and p50) and that the binding domain of Nucling is its amino-terminal region (amino acids 1-466) containing ankyrin repeats. Overexpression of Nucling prevents the translocation of nuclear factor-kappaB into the nucleus. In addition, the cytoplasmic retention of endogenous nuclear factor-kappaB in resting cells is not observed in Nucling gene-deficient mouse embryonic fibroblasts. These results reveal a novel function of Nucling as a suppressor of nuclear factor-kappaB, mediated by its cytoplasmic retention through physical interaction.  (日)    [継承]
キーワード (推奨): 1.IκBα (IκBα) [継承]
2.nuclear factor κB (nuclear factor κB) [継承]
3.核移行 (nuclear translocation) [継承]
4.ヌクリング (nucling) [継承]
5.tumor necrosis factor-α (tumor necrosis factor-α) [継承]
発行所 (推奨): Wiley-Blackwell [継承]
誌名 (必須): The FEBS Journal ([Federation of European Biochemical Societies])
(pISSN: 1742-464X, eISSN: 1742-4658)

ISSN (任意): 1742-4658
ISSN: 1742-464X (pISSN: 1742-464X, eISSN: 1742-4658)
Title: The FEBS journal
Title(ISO): FEBS J.
Supplier: Federation of European Biochemical Societies
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 276 [継承]
(必須): 5 [継承]
(必須): 1459 1470 [継承]
都市 (任意): ホボケン (Hoboken/[アメリカ合衆国]) [継承]
年月日 (必須): 西暦 2009年 3月 5日 (平成 21年 3月 5日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1742-4658.2009.06888.x    (→Scopusで検索) [継承]
PMID (任意): 19187222    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-60349104730 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Pathophysiology, Institute for Enzyme Research, University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Li Liu, Takashi Sakai, HoangNam Tran, Rika Mukai-Sakai, Ryuji Kaji and Kiyoshi Fukui : Nucling interacts with nuclear factor-B, regulating its cellular distribution, The FEBS Journal, Vol.276, No.5, 1459-1470, 2009.
欧文冊子 ● Li Liu, Takashi Sakai, HoangNam Tran, Rika Mukai-Sakai, Ryuji Kaji and Kiyoshi Fukui : Nucling interacts with nuclear factor-B, regulating its cellular distribution, The FEBS Journal, Vol.276, No.5, 1459-1470, 2009.

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