『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Nishimoto Makoto (日) (読)
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2. (英) Hata Takashi (日) (読)
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3.後藤 優樹 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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4.玉井 伸岳 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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5.金品 昌志
役割 (任意): (英)   (日) 解析,考察   [継承]
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6.松木 均 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意): (英)   (日) 計画,解析,考察,論文執筆の指導   [継承]
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7. (英) Ueda Issaku (日) (読)
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題名 (必須): (英) Interaction modes of long-chain fatty acids in dipalmitoylphosphatidylcholine bilayer membrane: contrast to mode of inhalation anesthetics  (日)    [継承]
副題 (任意):
要約 (任意): (英) The effects of long-chain fatty acids (four saturated and two unsaturated fatty acids, one derivative) on phase transitions of dipalmitoylphosphatidylcholine (DPPC) bilayer membranes were examined in the low concentration region, and the results were compared with those for an inhalation anesthetic. The effects of all fatty acids on the pre- and main-transition temperatures of the DPPC bilayer membrane appeared in the concentration range of microM order while that of the anesthetic appeared in the mM order. The appearance modes of these ligand actions were significantly different from one another. The three differential partition coefficients of the ligands between two phases of the DPPC bilayer membrane were evaluated by applying the thermodynamic equation to the variation of the phase-transition temperatures. The DPPC bilayer membranes showed the different receptivity for the ligands; the saturated fatty acids had an affinity for gel phase whereas unsaturated fatty acids and an anesthetic had an affinity for liquid-crystalline phase to the contrary. In particular, the receptivity for the ligands in the gel phase markedly changed depending on kinds of ligands. The interaction modes between the DPPC and fatty acid molecules in the gel phase were considered from the hexagonal lattice model. The disappearance compositions of the pretransition by the fatty acids coincided with the compositions at which the membrane is all covered by the units in each of which two fatty acids molecules are regularly distributed in the hexagonal lattice in a different way, and the distribution depended on the chain length and existence of a double bond for the fatty acids. The interpretation did not hold for the case of the anesthetic at all, which proved that a number of anesthetic molecules act the surface region of the bilayer membrane nonspecifically. The present study clearly implies that DPPC bilayer membranes have high ability to recognize kinds of ligand molecules and can discriminate among them with specific interaction by the membrane states.  (日)    [継承]
キーワード (推奨): 1. (英) 1,2-Dipalmitoylphosphatidylcholine (日) (読) [継承]
2. (英) Anesthetics (日) (読) [継承]
3. (英) Calorimetry, Differential Scanning (日) (読) [継承]
4. (英) Fatty Acids (日) (読) [継承]
5. (英) Lipid Bilayers (日) (読) [継承]
6. (英) Phase Transition (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Chemistry and Physics of Lipids ([Elsevier Science])
(pISSN: 0009-3084, eISSN: 1873-2941)

ISSN (任意): 1873-2941
ISSN: 0009-3084 (pISSN: 0009-3084, eISSN: 1873-2941)
Title: Chemistry and physics of lipids
Title(ISO): Chem Phys Lipids
Publisher: Elsevier BV
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年月日 (必須): 西暦 2009年 4月 初日 (平成 21年 4月 初日) [継承]
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DOI (任意): 10.1016/j.chemphyslip.2009.02.003    (→Scopusで検索) [継承]
PMID (任意): 19428351    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Minamijosanjima-cho, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Makoto Nishimoto, Takashi Hata, Masaki GOTO, Nobutake Tamai, Shoji Kaneshina, Hitoshi Matsuki and Issaku Ueda : Interaction modes of long-chain fatty acids in dipalmitoylphosphatidylcholine bilayer membrane: contrast to mode of inhalation anesthetics, Chemistry and Physics of Lipids, Vol.158, No.2, 71-80, 2009.
欧文冊子 ● Makoto Nishimoto, Takashi Hata, Masaki GOTO, Nobutake Tamai, Shoji Kaneshina, Hitoshi Matsuki and Issaku Ueda : Interaction modes of long-chain fatty acids in dipalmitoylphosphatidylcholine bilayer membrane: contrast to mode of inhalation anesthetics, Chemistry and Physics of Lipids, Vol.158, No.2, 71-80, 2009.

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