『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=186144EID:186144, Map:0, LastModified:2013年10月16日(水) 11:51:22, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[細井 和雄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座.口腔分子生理学 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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[継承]
2. (英) Azlina, Ahmad (日) (読)
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[継承]
3. (英) Purwanti, Nunuk (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Karabasil, Ratko, Mileva (日) (読)
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5.長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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学籍番号 (推奨):
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6.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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7.細井 和雄
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題名 (必須): (英) Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland  (日)    [継承]
副題 (任意):
要約 (任意): (英) The submandibular gland (SMG) develops through the epithelial-mesenchymal interaction mediated by many growth/differentiation factors including activin and BMPs, which are synthesized as inactive precursors and activated by subtilisin-like proprotein convertases (SPC) following cleavage at their R-X-K/R-R site. Here, we found that Dec-RVKR-CMK, a potent inhibitor of SPC, inhibited the branching morphogenesis of the rat embryonic SMG, and caused low expression of a water channel AQP5, in an organ culture system. Dec-RVKR-CMK also decreased the expression of PACE4, a SPC member, but not furin, another SPC member, suggesting the involvement of PACE4 in the SMG development. Heparin, which is known to translocate PACE4 in the extracellular matrix into the medium, and an antibody specific for the catalytic domain of PACE4, both reduced the branching morphogenesis and AQP5 expression in the SMG. The inhibitory effects of Dec-RVKR-CMK were partially rescued by the addition of recombinant BMP2, whose precursor is one of the candidate substrates for PACE4 in vivo. Further, the suppression of PACE4 expression by siRNAs resulted in decreased expression of AQP5 and inhibition of the branching morphogenesis in the present organ culture system. These observations suggest that PACE4 regulates the SMG development via the activation of some growth/differentiation factors.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Chloromethyl Ketones (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Aquaporin 5 (日) (読) [継承]
4. (英) Extracellular Matrix (日) (読) [継承]
5. (英) Furin (日) (読) [継承]
6. (英) Gene Silencing (日) (読) [継承]
7. (英) Heparin (日) (読) [継承]
8. (英) Morphogenesis (日) (読) [継承]
9. (英) Organ Culture Techniques (日) (読) [継承]
10. (英) Proprotein Convertases (日) (読) [継承]
11. (英) Rats (日) (読) [継承]
12. (英) Rats, Sprague-Dawley (日) (読) [継承]
13. (英) Submandibular Gland (日) (読) [継承]
発行所 (推奨): Elsevier.Elsevier Scientific Publishing Company [継承]
誌名 (必須): Developmental Biology (Society for Developmental Biology)
(pISSN: 0012-1606, eISSN: 1095-564X)

ISSN (任意): 1095-564X
ISSN: 0012-1606 (pISSN: 0012-1606, eISSN: 1095-564X)
Title: Developmental biology
Title(ISO): Dev Biol
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 325 [継承]
(必須): 2 [継承]
(必須): 434 443 [継承]
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年月日 (必須): 西暦 2009年 1月 15日 (平成 21年 1月 15日) [継承]
URL (任意):
DOI (任意): 10.1016/j.ydbio.2008.10.015    (→Scopusで検索) [継承]
PMID (任意): 19013448    (→Scopusで検索) [継承]
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WOS (任意): 000262589400012 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima-shi, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuya Akamatsu, Ahmad Azlina, Nunuk Purwanti, Mileva Ratko Karabasil, Takahiro Hasegawa, Chenjuan Yao and Kazuo Hosoi : Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland, Developmental Biology, Vol.325, No.2, 434-443, 2009.
欧文冊子 ● Tetsuya Akamatsu, Ahmad Azlina, Nunuk Purwanti, Mileva Ratko Karabasil, Takahiro Hasegawa, Chenjuan Yao and Kazuo Hosoi : Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland, Developmental Biology, Vol.325, No.2, 434-443, 2009.

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