『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=185485)

EID=185485EID:185485, Map:0, LastModified:2012年10月11日(木) 18:42:43, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[センター長]/[徳島大学.疾患プロテオゲノム研究センター]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Seach, N (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.上野 智雄
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Fletcher, A.L. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Lowen, T (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Matteshich, M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Engwerda, C (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Scott, H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Ware, C (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Chidgey, A.P. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Gray, D.H. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Boyd, R.L. (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Medullary thymic epithelial cells (mTEC) play an important and unique role in central tolerance, expressing tissue-restricted Ags (TRA) which delete thymocytes autoreactive to peripheral organs. Since deficiencies in this cell type or activity can lead to devastating autoimmune diseases, it is important to understand the factors which regulate mTEC differentiation and function. Lymphotoxin (LT) ligands and the LTbetaR have been recently shown to be important regulators of mTEC biology; however, the precise role of this pathway in the thymus is not clear. In this study, we have investigated the impact of this signaling pathway in greater detail, focusing not only on mTEC but also on other thymic stromal cell subsets. LTbetaR expression was found in all TEC subsets, but the highest levels were detected in MTS-15(+) thymic fibroblasts. Rather than directing the expression of the autoimmune regulator Aire in mTEC, we found LTbetaR signals were important for TRA expression in a distinct population of mTEC characterized by low levels of MHC class II (mTEC(low)), as well as maintenance of MTS-15(+) fibroblasts. In addition, thymic stromal cell subsets from LT-deficient mice exhibit defects in chemokine production similar to that found in peripheral lymphoid organs of Lta(-/-) and Ltbr(-/-) mice. Thus, we propose a broader role for LTalpha1beta2-LTbetaR signaling in the maintenance of the thymic microenvironments, specifically by regulating TRA and chemokine expression in mTEC(low) for efficient induction of central tolerance.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Clonal Deletion (日) (読) [継承]
3. (英) Cytokines (日) (読) [継承]
4. (英) Epithelial Cells (日) (読) [継承]
5. (英) Gene Expression (日) (読) [継承]
6. (英) Immune Tolerance (日) (読) [継承]
7. (英) Lymphotoxin beta Receptor (日) (読) [継承]
8. (英) Lymphotoxin-alpha (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C57BL (日) (読) [継承]
11. (英) Mice, Mutant Strains (日) (読) [継承]
12. (英) Stromal Cells (日) (読) [継承]
13. (英) Thymus Gland (日) (読) [継承]
14. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 180 [継承]
(必須): 8 [継承]
(必須): 5384 5392 [継承]
都市 (任意):
年月日 (必須): 西暦 2008年 4月 15日 (平成 20年 4月 15日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 18390720    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000257506900026 [継承]
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: NIHMS97705  (日)    [継承]
5.(英) OtherID: PMC2760078  (日)    [継承]

標準的な表示

和文冊子 ● N Seach, Tomoo Ueno, A.L. Fletcher, T Lowen, M Matteshich, C Engwerda, H Scott, C Ware, A.P. Chidgey, D.H. Gray and R.L. Boyd : The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells., The Journal of Immunology, Vol.180, No.8, 5384-5392, 2008.
欧文冊子 ● N Seach, Tomoo Ueno, A.L. Fletcher, T Lowen, M Matteshich, C Engwerda, H Scott, C Ware, A.P. Chidgey, D.H. Gray and R.L. Boyd : The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells., The Journal of Immunology, Vol.180, No.8, 5384-5392, 2008.

関連情報

Number of session users = 1, LA = 1.39, Max(EID) = 383267, Max(EOID) = 1024361.