『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=185202)

EID=185202EID:185202, Map:0, LastModified:2012年12月25日(火) 16:28:41, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[センター長]/[徳島大学.疾患プロテオゲノム研究センター]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.新田 剛
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Chiba Ayako (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Yamashita Atsuya (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Rowe Martin (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Israel Alain (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Reth Michael (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Yamamoto Naoki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Yamaoka Shoji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) NF-κB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus.  (日)    [継承]
副題 (任意):
要約 (任意): (英) NF-kappaB is a transcription factor known to promote or antagonize cell death depending on cell types and stimuli. Here, we demonstrate that expression of latent membrane protein 1 (LMP1), an Epstein-Barr virus (EBV)-encoded membrane protein, triggers programmed cell death in an NF-kappaB-dependent manner. Co-expression of NF-kappaB inhibitors completely prevented activation of NF-kappaB and LMP1-induced cell death. Addition therein of RelA, an active subunit of NF-kappaB, restored the NF-kappaB activation and cell death induction by LMP1, but RelA alone did not induce cell death. These results indicate that the activation of NF-kappaB is required for cell death induced by LMP1. Moreover, LMP1 induced activation of caspase-3 via the activation of NF-kappaB. Studies with z-VAD-fmk, a caspase inhibitor, indicated that NF-kappaB mediated both caspase-dependent and -independent death pathways. In conclusion, the cell death induced by LMP1 uncovered caspase-dependent and -independent death pathways both of which require NF-kappaB.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Caspase 3 (日) (読) [継承]
3. (英) Caspases (日) (読) [継承]
4. (英) Cell Death (日) (読) [継承]
5. (英) Cell Transformation, Viral (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Enzyme Activation (日) (読) [継承]
8. (英) NF-kappa B (日) (読) [継承]
9. (英) Plasmids (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11. (英) Transfection (日) (読) [継承]
12. (英) Viral Matrix Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cellular Signalling ([Elsevier])
(pISSN: 0898-6568, eISSN: 1873-3913)

ISSN (任意): 0898-6568
ISSN: 0898-6568 (pISSN: 0898-6568, eISSN: 1873-3913)
Title: Cellular signalling
Title(ISO): Cell Signal
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 15 [継承]
(必須): 4 [継承]
(必須): 423 433 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 4月 初日 (平成 15年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/S0898-6568(02)00141-9    (→Scopusで検索) [継承]
PMID (任意): 12618217    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Virology, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Nitta, Ayako Chiba, Atsuya Yamashita, Martin Rowe, Alain Israel, Michael Reth, Naoki Yamamoto and Shoji Yamaoka : NF-κB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus., Cellular Signalling, Vol.15, No.4, 423-433, 2003.
欧文冊子 ● Takeshi Nitta, Ayako Chiba, Atsuya Yamashita, Martin Rowe, Alain Israel, Michael Reth, Naoki Yamamoto and Shoji Yamaoka : NF-κB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus., Cellular Signalling, Vol.15, No.4, 423-433, 2003.

関連情報

Number of session users = 0, LA = 0.70, Max(EID) = 376450, Max(EOID) = 1008218.