『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.新田 剛
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
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2. (英) Chiba Ayako (日) (読)
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3. (英) Yamamoto Naoki (日) (読)
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4. (英) Yamaoka Shoji (日) (読)
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題名 (必須): (英) Lack of cytotoxic property in a variant of Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) is a membrane protein that activates multiple signaling pathways and transcription factors, including NF-kappaB. Our recent report demonstrated that expression of LMP1 induced programmed cell death in an NF-kappaB-dependent manner. In this study, we demonstrate that a variant CAO-LMP1 derived from EBV-infected nasopharyngeal carcinoma (NPC) does not induce cell death unlike the prototype B95.8-LMP1, although both types of LMP1 show NF-kappaB activation to a similar extent. Studies with chimeric or mutated proteins identified two amino acids in the transmembrane domain, which are commonly substituted in NPC-derived LMP1 variants, being critical for cell death induction by B95.8-LMP1. Furthermore, we show that the B95.8 transmembrane domain co-operates with NF-kappaB to trigger cell death program. Thus, our results reveal a particular feature of the transmembrane domain of tumor-derived CAO-LMP1 and suggest its possible contribution to the pathogenesis of NPC.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Caspases (日) (読) [継承]
4.細胞死 (cell death) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Cell Membrane (日) (読) [継承]
7. (英) Enzyme Activation (日) (読) [継承]
8. (英) Genetic Variation (日) (読) [継承]
9. (英) Herpesvirus 4, Human (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Mutagenesis (日) (読) [継承]
12. (英) NF-kappa B (日) (読) [継承]
13. (英) Nasopharyngeal Neoplasms (日) (読) [継承]
14. (英) Protein Structure, Tertiary (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Transfection (日) (読) [継承]
17. (英) Viral Matrix Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cellular Signalling ([Elsevier])
(pISSN: 0898-6568, eISSN: 1873-3913)

ISSN (任意): 0898-6568
ISSN: 0898-6568 (pISSN: 0898-6568, eISSN: 1873-3913)
Title: Cellular signalling
Title(ISO): Cell Signal
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 9 [継承]
(必須): 1071 1081 [継承]
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年月日 (必須): 西暦 2004年 9月 初日 (平成 16年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.cellsig.2004.03.001    (→Scopusで検索) [継承]
PMID (任意): 15212767    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000222545000010 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Virology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Nitta, Ayako Chiba, Naoki Yamamoto and Shoji Yamaoka : Lack of cytotoxic property in a variant of Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma., Cellular Signalling, Vol.16, No.9, 1071-1081, 2004.
欧文冊子 ● Takeshi Nitta, Ayako Chiba, Naoki Yamamoto and Shoji Yamaoka : Lack of cytotoxic property in a variant of Epstein-Barr virus latent membrane protein 1 isolated from nasopharyngeal carcinoma., Cellular Signalling, Vol.16, No.9, 1071-1081, 2004.

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