『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=185198)

EID=185198EID:185198, Map:0, LastModified:2012年12月25日(火) 16:54:31, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[大東 いずみ], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.新田 剛
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[継承]
2.Nasreen Mariam
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[継承]
3. (英) Seike Takafumi (日) (読)
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[継承]
4. (英) Goji Atsushi (日) (読)
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5.大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
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6. (英) Miyazaki Tadaaki (日) (読)
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7. (英) Ohta Tsutomu (日) (読)
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8. (英) Kanno Masamoto (日) (読)
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9.高浜 洋介
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題名 (必須): (英) IAN family critically regulates survival and development of T lymphocytes  (日)    [継承]
副題 (任意):
要約 (任意): (英) The IAN (immune-associated nucleotide-binding protein) family is a family of functionally uncharacterized GTP-binding proteins expressed in vertebrate immune cells and in plant cells during antibacterial responses. Here we show that all eight IAN family genes encoded in a single cluster of mouse genome are predominantly expressed in lymphocytes, and that the expression of IAN1, IAN4, and IAN5 is significantly elevated upon thymic selection of T lymphocytes. Gain-of-function experiments show that the premature overexpression of IAN1 kills immature thymocytes, whereas short hairpin RNA-mediated loss-of-function studies show that IAN4 supports positive selection. The knockdown of IAN5 perturbs the optimal generation of CD4/CD8 double-positive thymocytes and reduces the survival of mature T lymphocytes. We also show evidence suggesting that IAN4 and IAN5 are associated with anti-apoptotic proteins Bcl-2 and Bcl-xL, whereas IAN1 is associated with pro-apoptotic Bax. Thus, the IAN family is a novel family of T cell-receptor-responsive proteins that critically regulate thymic development and survival of T lymphocytes and that potentially exert regulatory functions through the association with Bcl-2 family proteins.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Apoptosis (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Cell Survival (日) (読) [継承]
5. (英) GTP-Binding Proteins (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Genome (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Molecular Sequence Data (日) (読) [継承]
10. (英) Phylogeny (日) (読) [継承]
11. (英) Protein Binding (日) (読) [継承]
12. (英) Proto-Oncogene Proteins c-bcl-2 (日) (読) [継承]
13. (英) RNA Interference (日) (読) [継承]
14. (英) T-Lymphocytes (日) (読) [継承]
15. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨):
誌名 (必須): PLoS Biology (Public Library of Science)
(pISSN: 1544-9173, eISSN: 1545-7885)

ISSN (任意): 1545-7885
ISSN: 1544-9173 (pISSN: 1544-9173, eISSN: 1545-7885)
Title: PLoS biology
Title(ISO): PLoS Biol
Publisher: Public Library of Science
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 4 [継承]
(必須): 4 [継承]
(必須): e103 e115 [継承]
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年月日 (必須): 西暦 2006年 3月 7日 (平成 18年 3月 7日) [継承]
URL (任意):
DOI (任意): 10.1371/journal.pbio.0040103    (→Scopusで検索) [継承]
PMID (任意): 16509771    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.DataBankList.DataBank.DataBankName: GENBANK  (日)    [継承]
3.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AB178029  (日)    [継承]
4.(英) Article.DataBankList.DataBank.DataBankName: RefSeq  (日)    [継承]
5.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: NM_018326  (日)    [継承]
6.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: NM_173153  (日)    [継承]
7.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: XM_144696  (日)    [継承]
8.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
9.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
10.(英) OtherID: PMC1393758  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Nitta, Mariam Nasreen, Takafumi Seike, Atsushi Goji, Izumi Ohigashi, Tadaaki Miyazaki, Tsutomu Ohta, Masamoto Kanno and Yousuke Takahama : IAN family critically regulates survival and development of T lymphocytes, PLoS Biology, Vol.4, No.4, e103-e115, 2006.
欧文冊子 ● Takeshi Nitta, Mariam Nasreen, Takafumi Seike, Atsushi Goji, Izumi Ohigashi, Tadaaki Miyazaki, Tsutomu Ohta, Masamoto Kanno and Yousuke Takahama : IAN family critically regulates survival and development of T lymphocytes, PLoS Biology, Vol.4, No.4, e103-e115, 2006.

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