『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1. (英) Iwana Sanae (日) 岩名 沙奈恵 (読) いわな さなえ
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2. (英) Kawazoe Tomoya (日) 川添 僚也 (読) かわぞえ ともや
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3. (英) Park Ki Hwan (日) 朴 煥埼 (読) ぱく はんき
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4.土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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5.小野 公嗣
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6.頼田 和子
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7.坂井 隆志
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8.楠見 武徳
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9.福井 清 ([徳島大学])
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題名 (必須): (英) Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia  (日)    [継承]
副題 (任意):
要約 (任意): (英) D-amino acid oxidase (DAO), a potential risk factor for schizophrenia, has been proposed to be involved in the decreased glutamatergic neurotransmission in schizophrenia. Here we show the inhibitory effect of an antipsychotic drug, chlorpromazine, on human DAO, which is consistent with previous reports using porcine DAO, although human DAO was inhibited to a lesser degree (K(i) = 0.7 mM) than porcine DAO. Since chlorpromazine is known to induce phototoxic or photoallergic reactions and also to be transformed into various metabolites, we examined the effects of white light-irradiated chlorpromazine on the enzymatic activity. Analytical methods including high-resolution mass spectrometry revealed that irradiation triggered the oligomerization of chlorpromazine molecules. The oligomerized chlorpromazine showed a mixed type inhibition with inhibition constants of low micromolar range, indicative of enhanced inhibition. Taken together, these results suggest that oligomerized chlorpromazine could act as an active substance that might contribute to the therapeutic effects of this drug.  (日)    [継承]
キーワード (推奨): 1.D-アミノ酸酸化酵素 (D-amino acid oxidase) [継承]
2.統合失調症 (schizophrenia) [継承]
3.クロルプロマジン (chlorpromazine) [継承]
4.オリゴマー (oligomer) [継承]
5.グルタミン酸性神経伝達 (glutamatergic neurotransmission) [継承]
6.阻害 (inhibition) [継承]
発行所 (推奨): Taylor & Francis [継承]
誌名 (必須): Journal of Enzyme Inhibition and Medicinal Chemistry ([Taylor & Francis])
(pISSN: 1475-6366, eISSN: 1475-6374)

ISSN (任意): 1475-6374
ISSN: 1475-6366 (pISSN: 1475-6366, eISSN: 1475-6374)
Title: Journal of enzyme inhibition and medicinal chemistry
Title(ISO): J Enzyme Inhib Med Chem
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 901 911 [継承]
都市 (任意): ロンドン (London/[連合王国]) [継承]
年月日 (必須): 西暦 2008年 12月 初日 (平成 20年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1080/14756360701745478    (→Scopusで検索) [継承]
PMID (任意): 18615285    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: The Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan. iwana@ier.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Sanae Iwana, Tomoya Kawazoe, Hwan Ki Park, Koichiro Tsuchiya, Koji Ono, Kazuko YORITA, Takashi Sakai, Takenori Kusumi and Kiyoshi Fukui : Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia, Journal of Enzyme Inhibition and Medicinal Chemistry, Vol.23, No.6, 901-911, 2008.
欧文冊子 ● Sanae Iwana, Tomoya Kawazoe, Hwan Ki Park, Koichiro Tsuchiya, Koji Ono, Kazuko YORITA, Takashi Sakai, Takenori Kusumi and Kiyoshi Fukui : Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia, Journal of Enzyme Inhibition and Medicinal Chemistry, Vol.23, No.6, 901-911, 2008.

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