『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=181446EID:181446, Map:0, LastModified:2012年10月11日(木) 19:09:34, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Paulino Niraldo (日) (読)
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2. (英) Abreu Sheila Rago Lemos (日) (読)
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3.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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4. (英) Koyama Daisuke (日) 小山 大輔 (読) こやま だいすけ
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5.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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6.堀 均
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7. (英) Dirsch M. Verena (日) (読)
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8. (英) Vollmar M. Angelika (日) (読)
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9. (英) Scremin Amarilis (日) (読)
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10. (英) Bretz A. Walter (日) (読)
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題名 (必須): (英) Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis  (日)    [継承]
副題 (任意):
要約 (任意): (英) Artepillin C is the major compound in the Brazilian green propolis from Baccharis dracunculifolia. Our aim in this study was to investigate the anti-inflammatory effects, absorption, and bioavailability of Artepillin C in mice. The animals used were male Swiss mice subjected to: paw oedema by carrageenan (300 μg/paw), carrageenan-induced peritonitis, and prostaglandin E2 determination. We also measured in vitro nitric oxide production by RAW 264.7 cells and NF-κB activity in HEK 293 cells. Finally, we measured the absorption and bioavailability of Artepillin C in plasma from mice by means of GC-MS after a single oral dose (10 mg/kg). In vivo, Artepillin C produced a maximal inhibition of 38% after 360 min on paw oedema. Artepillin C also decreased the number of neutrophils during peritonitis (IC50: 0.9 (0.5 1.4) mg/kg). Treatment with Artepillin C decreased prostaglandin E2 by 29 ± 3% and 58 ± 5% at 1 and 10 mg/kg, respectively, with a mean ID50 of 8.5 (8.0 8.7)mg/kg). Similarly, in in vitro models, Artepillin C (3, 10, or 100 μM) decreased nitric oxide production by RAW 264.7 cells with a mean IC50 of 8.5 (7.8 9.2) μM. In HEK 293 cells, Artepillin C reduced NF-κB activity with a mean IC50 of 26 (22 30) μg/ml), suggesting anti-inflammatory activity, particularly during acute inflammation. Lastly, Artepillin C was absorbed after an oral dose (10 mg/kg) with maximal peaks found at 1 h (22 μg/ml). Collectively, Artepillin C showed anti-inflammatory effects mediated, at least in part, by prostaglandin E2 and nitric oxide inhibition through NF-κB modulation, and exhibited bioavailability by oral administration.  (日)    [継承]
キーワード (推奨): 1. (英) Artepillin C (日) (読) [継承]
2. (英) Propolis (日) (読) [継承]
3. (英) Inflammation (日) (読) [継承]
4. (英) NF-κB (日) (読) [継承]
5. (英) Prostaglandin E2 (日) (読) [継承]
6. (英) Nitric oxide (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): European Journal of Pharmacology ([Elsevier])
(pISSN: 0014-2999, eISSN: 1879-0712)

ISSN (任意): 0014-2999
ISSN: 0014-2999 (pISSN: 0014-2999, eISSN: 1879-0712)
Title: European journal of pharmacology
Title(ISO): Eur. J. Pharmacol.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2008年 2月 29日 (平成 20年 2月 29日) [継承]
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DOI (任意): 10.1016/j.ejphar.2008.02.067    (→Scopusで検索) [継承]
PMID (任意): 18474366    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Programa de Pós-graduação em Farmácia, Universidade Bandeirante de São Paulo, São Paulo, Brazil. niraldop@yahoo.com.br  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Niraldo Paulino, Lemos Sheila Rago Abreu, Yoshihiro Uto, Daisuke Koyama, Hideko Nagasawa, Hitoshi Hori, Verena M. Dirsch, Angelika M. Vollmar, Amarilis Scremin and Walter A. Bretz : Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis, European Journal of Pharmacology, Vol.587, No.1-3, 296-301, 2008.
欧文冊子 ● Niraldo Paulino, Lemos Sheila Rago Abreu, Yoshihiro Uto, Daisuke Koyama, Hideko Nagasawa, Hitoshi Hori, Verena M. Dirsch, Angelika M. Vollmar, Amarilis Scremin and Walter A. Bretz : Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis, European Journal of Pharmacology, Vol.587, No.1-3, 296-301, 2008.

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